High LDL Particle and APOB Concentrations in Patients With Adrenal Cortical Adenomas

dc.contributor.authorSandooja, Rashi
dc.contributor.authorSaini, Jasmine
dc.contributor.authorKittithaworn, Annop
dc.contributor.authorGregg-Garcia, Raul
dc.contributor.authorDogra, Prerna
dc.contributor.authorAtkinson, Elizabeth
dc.contributor.authorYu, Kai
dc.contributor.authorFell, Vanessa
dc.contributor.authorSimha, Vinaya
dc.contributor.authorConnelly, Margery A.
dc.contributor.authorDullaart, Robin P. F.
dc.contributor.authorBancos, Irina
dc.contributor.departmentMedicine, School of Medicine
dc.date.accessioned2025-07-15T10:20:39Z
dc.date.available2025-07-15T10:20:39Z
dc.date.issued2024
dc.description.abstractContext: Patients with nonfunctioning adenomas (NFAs), adenomas with mild autonomous cortisol secretion (MACS) and Cushing syndrome (CS) demonstrate an increased cardiovascular risk. Objective: This work aimed to determine the extent of lipoprotein abnormalities in NFA, MACS, and CS. Methods: We conducted a single-center, cross-sectional study of patients with NFA (n = 167), MACS (n = 213), CS (n = 142), and referent individuals (n = 202) between January 2015 and July 2022. Triglyceride-rich lipoprotein particles (TRLP), low-density lipoprotein particles (LDLP), high-density lipoprotein particles (HDLP), their subclasses and sizes were measured using nuclear magnetic resonance spectroscopy. Multivariable logistic analyses were adjusted for age, sex, body mass index, smoking, hypertension, diabetes and lipid-lowering drug therapy. Results: In age- and sex-adjusted analysis, all patients categories demonstrated increased very large TRLP, large TRLP, and greater TRLP size (odds ratio [OR], 1.22-2.08) and total LDLP (OR, 1.22-1.75) and decreased LDL and HDL size compared to referent individuals. In fully adjusted analysis, LDLP concentrations remained elevated in all patient categories (OR, 1.31-1.84). Total cholesterol, LDL cholesterol, triglycerides, and apolipoprotein B (ApoB) were also higher in all patient categories in age- and sex-adjusted analysis, with ApoB remaining elevated in all patient categories in fully adjusted analysis. Similar LDLP and ApoB elevations were observed in all patient categories after excluding individuals on lipid-lowering therapy. Conclusion: Patients with overt, mild, and even absent cortisol excess demonstrate lipoprotein profile abnormalities, in particular, high LDLP and ApoB concentrations, which conceivably contribute to high cardiometabolic risk.
dc.identifier.citationSandooja R, Saini J, Kittithaworn A, et al. High LDL Particle and APOB Concentrations in Patients With Adrenal Cortical Adenomas. J Clin Endocrinol Metab. 2024;110(1):195-207. doi:10.1210/clinem/dgae392
dc.identifier.urihttps://hdl.handle.net/1805/49460
dc.language.isoen_US
dc.publisherOxford University Press
dc.relation.isversionof10.1210/clinem/dgae392
dc.relation.journalThe Journal of Clinical Endocrinology and Metabolism
dc.rightsPublisher Policy
dc.sourcePMC
dc.subjectMACS
dc.subjectMild autonomous cortisol secretion
dc.subjectCortisol
dc.subjectCushing syndrome
dc.subjectLipoprotein particle
dc.subjectNuclear magnetic resonance spectroscopy
dc.titleHigh LDL Particle and APOB Concentrations in Patients With Adrenal Cortical Adenomas
dc.typeArticle
ul.alternative.fulltexthttps://pmc.ncbi.nlm.nih.gov/articles/PMC11651699/
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