Vitamin D levels and menopause-related symptoms.
dc.contributor.author | LeBlanc, Erin S. | |
dc.contributor.author | Desai, Manisha | |
dc.contributor.author | Perrin, Nancy | |
dc.contributor.author | Wactawski-Wende, Jean | |
dc.contributor.author | Manson, JoAnn E. | |
dc.contributor.author | Cauley, Jane A. | |
dc.contributor.author | Michael, Yvonne L. | |
dc.contributor.author | Tang, Jean | |
dc.contributor.author | Womack, Catherine | |
dc.contributor.author | Song, Yiqing | |
dc.contributor.author | Johnson, Karen C. | |
dc.contributor.author | O’Sullivan, Mary J. | |
dc.contributor.author | Woods, Nancy | |
dc.contributor.author | Stefanick, Marcia L. | |
dc.contributor.department | Department of Epidemiology, Richard M. Fairbanks School of Public Health | en_US |
dc.date.accessioned | 2016-03-30T23:19:39Z | |
dc.date.available | 2016-03-30T23:19:39Z | |
dc.date.issued | 2014-11 | |
dc.description.abstract | Objective: To determine whether vitamin D levels are associated with menopause-related symptoms in older women. Methods: A randomly selected subset of 1,407 women, among 26,104 potentially eligible participants of the Women’s Health Initiative Calcium and Vitamin D (CaD) trial of postmenopausal women aged 51-80 years, had 25-hydroxyvitamin D [25(OH)D] levels measured at the CaD trial baseline visit. Information about menopause-related symptoms at baseline was obtained by questionnaire and included overall number of symptoms and composite measures of sleep disturbance, emotional well-being, and energy/fatigue, as well as individual symptoms. After exclusions for missing data, 530 women [mean age 66.2 years (SD 6.8)] were included in these analyses. Results: There were borderline significant associations between 25(OH)D levels and total number of menopausal symptoms (p values ranging from 0.05 to 0.06 for fully adjusted models); however, the effect was clinically insignificant and disappeared with correction for multiple testing. There were no associations between 25(OH)D levels and composite measures of sleep disturbance, emotional well-being, or energy/fatigue (p’s > 0.10 for fully adjusted models). Conclusions: There was no evidence of a clinically important association between serum 25(OH)D levels and menopause-related symptoms in postmenopausal women. | en_US |
dc.eprint.version | Author's manuscript | en_US |
dc.identifier.citation | LeBlanc, E. S., Desai, M., Perrin, N., Wactawski-Wende, J., Manson, J. E., Cauley, J. A., … Stefanick, M. L. (2014). Vitamin D levels and menopause-related symptoms: Menopause, 21(11), 1197–1203. http://doi.org/10.1097/GME.0000000000000238 | en_US |
dc.identifier.issn | 1072-3714 1530-0374 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/9100 | |
dc.language.iso | en_US | en_US |
dc.publisher | Wolters Kluwer Health | en_US |
dc.relation.isversionof | 10.1097/GME.0000000000000238 | en_US |
dc.relation.journal | Menopause (New York, N.Y.) | en_US |
dc.rights | Publisher's policy | en_US |
dc.source | PMC | en_US |
dc.subject | Vitamin D | en_US |
dc.subject | menopause | en_US |
dc.subject | hot flashes | en_US |
dc.subject | mood | en_US |
dc.subject | sleep | en_US |
dc.title | Vitamin D levels and menopause-related symptoms. | en_US |
dc.type | Article | en_US |
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