Organic Photoredox Catalyzed Direct Hydroamination of Ynamides with Azoles
dc.contributor.author | Wang, Ban | |
dc.contributor.author | Mccabe, Gavin E. | |
dc.contributor.author | Parrish, Mitchell J. | |
dc.contributor.author | Singh, Jujhar | |
dc.contributor.author | Zeller, Matthias | |
dc.contributor.author | Deng, Yongming | |
dc.contributor.department | Chemistry and Chemical Biology, School of Science | en_US |
dc.date.accessioned | 2022-09-07T20:55:10Z | |
dc.date.available | 2022-09-07T20:55:10Z | |
dc.date.issued | 2022-03-15 | |
dc.description.abstract | Disclosed herein is a photoinduced selective hydroamination of ynamides with nitrogen heteroaromatic nucleophiles. By using an organocatalytic photoredox system, a direct method to construct a diverse of (Z)-α-azole enamides from ynamides and pyrazoles, as well as triazoles, benzotriazoles, indazoles, and tetrazoles, is developed, thus providing a photocatalytically synthetic route to heterocyclic motifs common in medicinal agents. Based on the mechanistic studies, the hydroamination is postulated to operate via a mechanism in which the single-electron oxidation of ynamide and the intermediacy of an alkyne radical cation, is responsible for the observed reactivity. | en_US |
dc.eprint.version | Author's manuscript | en_US |
dc.identifier.citation | Wang, B., Mccabe, G. E., Parrish, M. J., Singh, J., Zeller, M., & Deng, Y. (2022). Organic Photoredox Catalyzed Direct Hydroamination of Ynamides with Azoles. Advanced Synthesis & Catalysis, 364(6), 1179–1184. https://doi.org/10.1002/adsc.202101410 | en_US |
dc.identifier.issn | 1615-4150, 1615-4169 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/29957 | |
dc.language.iso | en_US | en_US |
dc.publisher | Wiley | en_US |
dc.relation.isversionof | 10.1002/adsc.202101410 | en_US |
dc.relation.journal | Advanced Synthesis & Catalysis | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | Author | en_US |
dc.subject | hydroamination | en_US |
dc.subject | ynamides | en_US |
dc.subject | alkyne transformations | en_US |
dc.title | Organic Photoredox Catalyzed Direct Hydroamination of Ynamides with Azoles | en_US |
dc.type | Article | en_US |