Histamine H2-Receptor Antagonists Use Is Associated with Lower Prevalence of Nonalcoholic Fatty Liver Disease: A Population-Based Study from the National Health and Nutrition Examination Survey, 2001-2006

dc.contributor.authorShen, Huafeng
dc.contributor.authorLiangpunsakul, Suthat
dc.contributor.departmentMedicine, School of Medicineen_US
dc.date.accessioned2018-02-26T15:11:02Z
dc.date.available2018-02-26T15:11:02Z
dc.date.issued2016-08
dc.description.abstractBackground & Aim Recent basic mechanistic studies found that proton pump inhibitors (PPIs) or histamine antagonists inhibited multiple pathways involved in non-alcoholic fatty liver disease (NAFLD) development. The aim of this study was to investigate an association between PPIs or H1/H2-receptor antagonists (H1RAs/H2RAs) use and NAFLD prevalence in the general US population. Methods We conducted a cross-sectional analysis of data from the National Health and Nutrition Examination Survey, 2001 – 2006. We included 10,398 adults aged 20 – 74 years who had alanine aminotransferase (ALT) data; of those, 2,058 were identified as having NAFLD and 8,340 as controls. PPIs or H1RAs/H2RAs use was defined as use of prescription medications in the preceding month. The length of use was categorized as ≤ 60 days and > 60 days. NAFLD was defined as elevated serum aminotransferases without any indication of other causes of chronic liver disease. Results In the multivariate unconditional logistic regression analysis, H2RAs use was inversely associated with prevalent NAFLD (odds ratio [OR] = 0.43, 95% confidence interval [CI] 0.18 – 0.99), a finding that was primarily limited to men (OR = 0.18, 95% CI 0.04 – 0.79) and those with insulin resistance (OR = 0.22, 95% CI 0.05 – 0.95). However, no significant associations were found between PPIs or H1RAs use and prevalent NAFLD. Conclusion These findings, from the first human study to investigate an association of PPIs or H1RAs/H2RAs use with NAFLD, suggest that H2RAs use may be associated with a lower prevalence of NAFLD, primarily among men with insulin resistance.en_US
dc.eprint.versionAuthor's manuscripten_US
dc.identifier.citationShen, H., & Liangpunsakul, S. (2016). Histamine H2-Receptor Antagonists Use Is Associated with Lower Prevalence of Nonalcoholic Fatty Liver Disease: A Population-Based Study from the National Health and Nutrition Examination Survey, 2001-2006. Journal of Clinical Gastroenterology, 50(7), 596–601. https://doi.org/10.1097/MCG.0000000000000503en_US
dc.identifier.issn0192-0790en_US
dc.identifier.urihttps://hdl.handle.net/1805/15268
dc.language.isoen_USen_US
dc.publisherWolters Kluweren_US
dc.relation.isversionof10.1097/MCG.0000000000000503en_US
dc.relation.journalJournal of clinical gastroenterologyen_US
dc.rightsPublisher Policyen_US
dc.sourcePMCen_US
dc.subjecthistamine antagonistsen_US
dc.subjectproton pump inhibitoren_US
dc.subjectNAFLDen_US
dc.titleHistamine H2-Receptor Antagonists Use Is Associated with Lower Prevalence of Nonalcoholic Fatty Liver Disease: A Population-Based Study from the National Health and Nutrition Examination Survey, 2001-2006en_US
dc.typeArticleen_US
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