Tau Imaging in Alzheimer's Disease Diagnosis and Clinical Trials

Simple item page
dc.contributor.authorBrosch, Jared R.
dc.contributor.authorFarlow, Martin R.
dc.contributor.authorRisacher, Shannon L.
dc.contributor.authorApostolova, Liana G.
dc.contributor.departmentNeurology, School of Medicineen_US
dc.date.accessioned2018-05-24T12:32:28Z
dc.date.available2018-05-24T12:32:28Z
dc.date.issued2017-01
dc.description.abstractIn vivo imaging of the tau protein has the potential to aid in quantitative diagnosis of Alzheimer's disease, corroborate or dispute the amyloid hypothesis, and demonstrate biomarker engagement in clinical drug trials. A host of tau positron emission tomography agents have been designed, validated, and tested in humans. Several agents have characteristics approaching the ideal imaging tracer with some limitations, primarily regarding off-target binding. Dozens of clinical trials evaluating imaging techniques and several pharmaceutical trials have begun to integrate tau imaging into their protocols.en_US
dc.eprint.versionFinal published versionen_US
dc.identifier.citationBrosch, J. R., Farlow, M. R., Risacher, S. L., & Apostolova, L. G. (2017). Tau Imaging in Alzheimer’s Disease Diagnosis and Clinical Trials. Neurotherapeutics, 14(1), 62–68. http://doi.org/10.1007/s13311-016-0490-yen_US
dc.identifier.urihttps://hdl.handle.net/1805/16240
dc.language.isoen_USen_US
dc.publisherSpringer Verlagen_US
dc.relation.isversionof10.1007/s13311-016-0490-yen_US
dc.relation.journalNeurotherapeuticsen_US
dc.rightsPublisher Policyen_US
dc.sourcePMCen_US
dc.subjectAlzheimer’s diseaseen_US
dc.subjectTauen_US
dc.subjectTau imagingen_US
dc.titleTau Imaging in Alzheimer's Disease Diagnosis and Clinical Trialsen_US
dc.typeArticleen_US
ul.alternative.fulltexthttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5233632/en_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
13311_2016_Article_490.pdf
Size:
2.05 MB
Format:
Adobe Portable Document Format
Description:
Main article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.99 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Open Access Policy Articles
Department of Neurology Works