Effects of acute alcohol exposure and chronic alcohol use on neurite orientation dispersion and density imaging (NODDI) parameters

dc.contributor.authorYoder, Karmen K.
dc.contributor.authorChumin, Evgeny J.
dc.contributor.authorMustafi, Sourajit M.
dc.contributor.authorKolleck, Kelly A.
dc.contributor.authorHalcomb, Meredith E.
dc.contributor.authorHile, Karen L.
dc.contributor.authorPlawecki, Martin H.
dc.contributor.authorO’Connor, Sean J.
dc.contributor.authorDzemidzic, Mario
dc.contributor.authorWu, Yu‑Chien
dc.contributor.departmentRadiology and Imaging Sciences, School of Medicine
dc.date.accessioned2024-03-22T15:34:46Z
dc.date.available2024-03-22T15:34:46Z
dc.date.issued2023
dc.description.abstractRationale: Little is known about how acute and chronic alcohol exposure may alter the in vivo membrane properties of neurons. Objectives: We employed neurite orientation dispersion and density imaging (NODDI) to examine acute and chronic effects of alcohol exposure on neurite density. Methods: Twenty-one healthy social drinkers (CON) and thirteen nontreatment-seeking individuals with alcohol use disorder (AUD) underwent a baseline multi-shell diffusion magnetic resonance imaging (dMRI) scan. A subset (10 CON, 5 AUD) received dMRI during intravenous infusions of saline and alcohol during dMRI. NODDI parametric images included orientation dispersion (OD), isotropic volume fraction (ISOVF), and corrected intracellular volume fraction (cICVF). Diffusion tensor imaging metrics of fractional anisotropy and mean, axial, and radial diffusivity (FA, MD, AD, RD) were also computed. Average parameter values were extracted from white matter (WM) tracts defined by the Johns Hopkins University atlas. Results: There were group differences in FA, RD, MD, OD, and cICVF, primarily in the corpus callosum. Both saline and alcohol had effects on AD and cICVF in WM tracts proximal to the striatum, cingulate, and thalamus. This is the first work to indicate that acute fluid infusions may alter WM properties, which are conventionally believed to be insensitive to acute pharmacological challenges. It also suggests that the NODDI approach may be sensitive to transient changes in WM. The next steps should include determining if the effect on neurite density differs with solute or osmolality, or both, and translational studies to assess how alcohol and osmolality affect the efficiency of neurotransmission.
dc.eprint.versionAuthor's manuscript
dc.identifier.citationYoder KK, Chumin EJ, Mustafi SM, et al. Effects of acute alcohol exposure and chronic alcohol use on neurite orientation dispersion and density imaging (NODDI) parameters. Psychopharmacology (Berl). 2023;240(7):1465-1472. doi:10.1007/s00213-023-06380-0
dc.identifier.urihttps://hdl.handle.net/1805/39448
dc.language.isoen_US
dc.publisherSpringer
dc.relation.isversionof10.1007/s00213-023-06380-0
dc.relation.journalPsychopharmacology
dc.rightsPublisher Policy
dc.sourcePMC
dc.subjectAcute alcohol intoxication
dc.subjectAlcohol
dc.subjectAlcohol use disorder
dc.subjectAxonal density
dc.subjectDiffusion-weighted imaging
dc.subjectNeurite
dc.subjectOsmolality
dc.subjectWhite matter
dc.titleEffects of acute alcohol exposure and chronic alcohol use on neurite orientation dispersion and density imaging (NODDI) parameters
dc.typeArticle
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