Aberrations of anterior insular cortex functional connectivity in nontreatment-seeking alcoholics

dc.contributor.authorHalcomb, Meredith E.
dc.contributor.authorChumin, Evgeny J.
dc.contributor.authorGoñi, Joaquín
dc.contributor.authorDzemidzic, Mario
dc.contributor.authorYoder, Karmen K.
dc.contributor.departmentRadiology and Imaging Sciences, School of Medicineen_US
dc.date.accessioned2019-02-06T18:04:31Z
dc.date.available2019-02-06T18:04:31Z
dc.date.issued2019-02
dc.description.abstractAn emergent literature suggests that resting state functional magnetic resonance imaging (rsfMRI) functional connectivity (FC) patterns are aberrant in alcohol use disorder (AUD) populations. The salience network (SAL) is an established set of brain regions prominent in salience attribution and valuation, and includes the anterior insular cortex (AIC). The SAL is thought to play a role in AUD through directing increased attention to interoceptive cues of intoxication. There is very little information on the salience network (SAL) in AUD, and, in particular, there are no data on SAL FC in currently drinking, nontreatment seeking individuals with AUD (NTS). rsfMRI data from 16 NTS and 21 social drinkers (SD) were compared using FC correlation maps from ten seed regions of interest in the bilateral AIC. As anticipated, SD subjects demonstrated greater insular FC with frontal and parietal regions. We also found that, compared to SD, NTS had higher insular FC with hippocampal and medial orbitofrontal regions. The apparent overactivity in brain networks involved in salience, learning, and behavioral control in NTS suggests possible mechanisms in the development and maintenance of AUD.en_US
dc.eprint.versionAuthor's manuscripten_US
dc.identifier.citationHalcomb, M. E., Chumin, E. J., Goñi, J., Dzemidzic, M., & Yoder, K. K. (2019). Aberrations of anterior insular cortex functional connectivity in nontreatment-seeking alcoholics. Psychiatry Research: Neuroimaging, 284, 21–28. https://doi.org/10.1016/j.pscychresns.2018.12.016en_US
dc.identifier.urihttps://hdl.handle.net/1805/18310
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.pscychresns.2018.12.016en_US
dc.relation.journalPsychiatry Research: Neuroimagingen_US
dc.rightsPublisher Policyen_US
dc.sourceAuthoren_US
dc.subjectalcohol use disorderen_US
dc.subjectresting state functional magnetic resonance imagingen_US
dc.subjectsalience networken_US
dc.titleAberrations of anterior insular cortex functional connectivity in nontreatment-seeking alcoholicsen_US
dc.typeArticleen_US
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