Primaquine plus artemisinin combination therapy for reduction of malaria transmission: promise and risk

dc.contributor.authorJohn, Chandy C.
dc.contributor.departmentDepartment of Pediatrics, IU School of Medicineen_US
dc.date.accessioned2016-08-31T18:16:21Z
dc.date.available2016-08-31T18:16:21Z
dc.date.issued2016
dc.description.abstractReduction of gametocyte transmission from humans to mosquitoes is a key component of malaria elimination. The study by Gonçalves and colleagues provides valuable new data on how the addition of low-dose primaquine to artemether-lumefantrine affects reduction of gametocytemia and transmission of gametocytes to mosquitoes in asymptomatically Plasmodium falciparum-infected children without G6PD deficiency, and on the degree to which low-dose primaquine affects hemoglobin levels in these children. The study sets the stage for future research required for consideration of an artemisinin combination therapy (ACT)-primaquine regimen in mass drug administration campaigns. Future studies will need to evaluate toxicity in adults and G6PD deficient persons, assess gametocyte transmission from adults, evaluate different ACT drugs with primaquine, and assess the implications of "rare" toxicities in large treatment populations, such as hemolysis requiring blood transfusion. The study highlights both the promise and the potential risk of ACT-primaquine treatment in malaria elimination campaigns.Please see related article: https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-016-0581-y .en_US
dc.eprint.versionFinal published versionen_US
dc.identifier.citationJohn, C. C. (2016). Primaquine plus artemisinin combination therapy for reduction of malaria transmission: promise and risk. BMC Medicine, 14, 65. http://doi.org/10.1186/s12916-016-0611-9en_US
dc.identifier.issn1741-7015en_US
dc.identifier.urihttps://hdl.handle.net/1805/10802
dc.language.isoen_USen_US
dc.publisherSpringer (Biomed Central Ltd.)en_US
dc.relation.isversionof10.1186/s12916-016-0611-9en_US
dc.relation.journalBMC medicineen_US
dc.rightsAttribution 3.0 United States
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/us
dc.sourcePMCen_US
dc.subjectArtemether-lumefantrineen_US
dc.subjectArtemisinin combination therapyen_US
dc.subjectFalciparumen_US
dc.subjectGametocyteen_US
dc.subjectHemolysisen_US
dc.subjectMalariaen_US
dc.subjectMass drug administrationen_US
dc.subjectMembrane feeding assayen_US
dc.subjectPrimaquineen_US
dc.subjectTransmissionen_US
dc.titlePrimaquine plus artemisinin combination therapy for reduction of malaria transmission: promise and risken_US
dc.typeArticleen_US
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