Pyridine-enabled copper-promoted cross dehydrogenative coupling of C(sp2)–H and unactivated C(sp3)–H bonds
dc.contributor.author | Wu, Xuesong | |
dc.contributor.author | Zhao, Yan | |
dc.contributor.author | Ge, Haibo | |
dc.contributor.department | Department of Chemistry & Chemical Biology, School of Science | en_US |
dc.date.accessioned | 2016-04-13T14:22:08Z | |
dc.date.available | 2016-04-13T14:22:08Z | |
dc.date.issued | 2015-07 | |
dc.description.abstract | The pyridine-enabled cross dehydrogenative coupling of sp2 C–H bonds of polyfluoroarenes and unactivated sp3 C–H bonds of amides was achieved via a copper-promoted process with good functional group compatibility. This reaction showed great site-selectivity by favoring the sp2 C–H bonds ortho to two fluoro atoms of arenes and the sp3 C–H bonds of α-methyl groups over those of the α-methylene, β- or γ-methyl groups of the aliphatic amides. Mechanistic studies revealed that sp3 C–H bond cleavage is an irreversible but not the rate-determining step, and the sp2 C–H functionalization of arenes appears precedent to the sp3 C–H functionalization of amides in this process. | en_US |
dc.eprint.version | Final published version | en_US |
dc.identifier.citation | Wu, X., Zhao, Y., & Ge, H. (2015). Pyridine-enabled copper-promoted cross dehydrogenative coupling of C (sp 2)–H and unactivated C (sp 3)–H bonds. Chemical Science, 6(10), 5978-5983. doi: 10.1039/C5SC02143J | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/9290 | |
dc.language.iso | en | en_US |
dc.publisher | Royal Society of Chemistry | en_US |
dc.relation.isversionof | 10.1039/C5SC02143J | en_US |
dc.relation.journal | Chemical Science | en_US |
dc.rights | Attribution 3.0 United States | |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | |
dc.source | Publisher | en_US |
dc.subject | Copper-promoted cross dehydrogenative coupling (CDC) reactions | en_US |
dc.subject | cross coupling reactions | en_US |
dc.title | Pyridine-enabled copper-promoted cross dehydrogenative coupling of C(sp2)–H and unactivated C(sp3)–H bonds | en_US |
dc.type | Article | en_US |