Acceptance and commitment therapy for patient fatigue interference and caregiver burden in advanced gastrointestinal cancer: Results of a pilot randomized trial

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dc.contributor.authorMosher, Catherine E.
dc.contributor.authorSecinti, Ekin
dc.contributor.authorWu, Wei
dc.contributor.authorKashy, Deborah A.
dc.contributor.authorKroenke, Kurt
dc.contributor.authorBricker, Jonathan B.
dc.contributor.authorHelft, Paul R.
dc.contributor.authorTurk, Anita A.
dc.contributor.authorLoehrer, Patrick J., Sr.
dc.contributor.authorSehdev, Amikar
dc.contributor.authorAl-Hader, Ahmad A.
dc.contributor.authorChampion, Victoria L.
dc.contributor.authorJohns, Shelley A.
dc.contributor.departmentPsychology, School of Science
dc.date.accessioned2024-01-31T17:32:07Z
dc.date.available2024-01-31T17:32:07Z
dc.date.issued2022
dc.description.abstractBackground: Fatigue often interferes with functioning in patients with advanced cancer, resulting in increased family caregiver burden. Acceptance and commitment therapy, a promising intervention for cancer-related suffering, has rarely been applied to dyads coping with advanced cancer. Aim: To examine the feasibility, acceptability, and preliminary efficacy of acceptance and commitment therapy for patient-caregiver dyads coping with advanced gastrointestinal cancer. Primary outcomes were patient fatigue interference and caregiver burden. Design: In this pilot trial, dyads were randomized to six weekly sessions of telephone-delivered acceptance and commitment therapy or education/support, an attention control. Outcomes were assessed at baseline and at 2 weeks and 3 months post-intervention. Setting/participants: Forty patients with stage III-IV gastrointestinal cancer and fatigue interference and family caregivers with burden or distress were recruited from two oncology clinics and randomized. Results: The eligibility screening rate (54%) and retention rate (81% at 2 weeks post-intervention) demonstrated feasibility. At 2 weeks post-intervention, acceptance and commitment therapy participants reported high intervention helpfulness (mean=4.25/5.00). Group differences in outcomes were not statistically significant. However, when examining within-group change, acceptance and commitment therapy patients showed moderate decline in fatigue interference at both follow-ups, whereas education/support patients did not show improvement at either follow-up. Acceptance and commitment therapy caregivers showed medium decline in burden at 2 weeks that was not sustained at 3 months, whereas education/support caregivers showed little change in burden. Conclusions: Acceptance and commitment therapy showed strong feasibility, acceptability, and promise and warrants further testing.
dc.eprint.versionAuthor's manuscript
dc.identifier.citationMosher CE, Secinti E, Wu W, et al. Acceptance and commitment therapy for patient fatigue interference and caregiver burden in advanced gastrointestinal cancer: Results of a pilot randomized trial. Palliat Med. 2022;36(7):1104-1117. doi:10.1177/02692163221099610
dc.identifier.urihttps://hdl.handle.net/1805/38244
dc.language.isoen_US
dc.publisherSage
dc.relation.isversionof10.1177/02692163221099610
dc.relation.journalPalliative Medicine
dc.rightsPublisher Policy
dc.sourcePMC
dc.subjectNeoplasms
dc.subjectFatigue
dc.subjectQuality of life
dc.subjectAcceptance and commitment therapy
dc.subjectFamily caregivers
dc.subjectCaregiver burden
dc.subjectClinical trial
dc.titleAcceptance and commitment therapy for patient fatigue interference and caregiver burden in advanced gastrointestinal cancer: Results of a pilot randomized trial
dc.typeArticle
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