Does prostate acinar adenocarcinoma with Gleason Score 3 + 3 = 6 have the potential to metastasize?
dc.contributor.author | Montironi, Rodolfo | |
dc.contributor.author | Scarpelli, Marina | |
dc.contributor.author | Mazzucchelli, Roberta | |
dc.contributor.author | Lopez-Beltran, Antonio | |
dc.contributor.author | Santoni, Matteo | |
dc.contributor.author | Briganti, Alberto | |
dc.contributor.author | Montorsi, Francesco | |
dc.contributor.author | Cheng, Liang | |
dc.contributor.department | Department of Pathology & Laboratory Medicine, School of Medicine | en_US |
dc.date.accessioned | 2015-10-30T19:33:30Z | |
dc.date.available | 2015-10-30T19:33:30Z | |
dc.date.issued | 2014-10-18 | |
dc.description.abstract | Background: There is a worldwide debate involving clinicians, uropathologists as well as patients and their families on whether Gleason score 6 adenocarcinoma should be labelled as cancer. Case description: We report a case of man diagnosed with biopsy Gleason score 6 acinar adenocarcinoma and classified as low risk (based on a PSA of 5 ng/mL and stage cT2a) whose radical prostatectomy specimen initially showed organ confined Gleason score 3 + 3 = 6, WHO nuclear grade 3, acinar adenocarcinoma with lymphovascular invasion and secondary deposit in a periprostatic lymph node. When deeper sections were cut to the point that almost all the slice present in the paraffin block was sectioned, a small tumor area (<5% of the whole tumor) of Gleason pattern 4 (poorly formed glands) was found in an extraprostatic position. Conclusion: The epilogue was that the additional finding changed the final Gleason score to 3 + 3 = 6 with tertiary pattern 4 and the stage to pT3a. Virtual Slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/ vs/13000_2014_190 | en_US |
dc.identifier.citation | Montironi, R., Scarpelli, M., Mazzucchelli, R., Lopez-Beltran, A., Santoni, M., Briganti, A., … Cheng, L. (2014). Does prostate acinar adenocarcinoma with Gleason Score 3 + 3 = 6 have the potential to metastasize? Diagnostic Pathology, 9, 190. http://doi.org/10.1186/s13000-014-0190-z | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/7303 | |
dc.language.iso | en_US | en_US |
dc.publisher | BioMed Central | en_US |
dc.relation.isversionof | 10.1186/s13000-014-0190-z | en_US |
dc.relation.journal | Diagnostic Pathology | en_US |
dc.rights | Attribution 3.0 United States | |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | |
dc.source | PMC | en_US |
dc.subject | Prostate cancer | en_US |
dc.subject | Gleason score 6 adenocarcinoma | en_US |
dc.subject | Gleason score | en_US |
dc.subject | Lymphovascular invasion | en_US |
dc.subject | Lymph node metastasis | en_US |
dc.subject | Periprostatic lymph node | en_US |
dc.title | Does prostate acinar adenocarcinoma with Gleason Score 3 + 3 = 6 have the potential to metastasize? | en_US |
dc.type | Article | en_US |