Pten loss induces autocrine FGF signaling to promote skin tumorigenesis

dc.contributor.authorHertzler-Schaefer, Kristina
dc.contributor.authorMathew, Grinu
dc.contributor.authorSomani, Ally-Khan
dc.contributor.authorTholpady, Sunil
dc.contributor.authorKadakia, Madhavi P.
dc.contributor.authorChen, Yiping
dc.contributor.authorSpandau, Dan F.
dc.contributor.authorZhang, Xin
dc.contributor.departmentDermatology, School of Medicine
dc.date.accessioned2025-04-14T11:47:59Z
dc.date.available2025-04-14T11:47:59Z
dc.date.issued2014
dc.description.abstractInactivation of the Pten tumor suppressor negatively regulates the PI3K-mTOR pathway. In a model of cutaneous squamous cell carcinoma (SCC), we demonstrate that deletion of Pten strongly elevates Fgf10 protein levels without increasing Fgf10 transcription in vitro and in vivo. The translational activation of Fgf10 by Pten deletion is reversed by genetic disruption of the mTORC1 complex, which also prevents skin tumorigenesis in Pten mutants. We further show that ectopic expression of Fgf10 causes skin papillomas, whereas Pten deletion-induced skin tumors are inhibited by epidermal deletion of Fgfr2. Collectively, our data identify autocrine activation of FGF signaling as an essential mechanism in promoting Pten-deficient skin tumors.
dc.eprint.versionAuthor's manuscript
dc.identifier.citationHertzler-Schaefer K, Mathew G, Somani AK, et al. Pten loss induces autocrine FGF signaling to promote skin tumorigenesis. Cell Rep. 2014;6(5):818-826. doi:10.1016/j.celrep.2014.01.045
dc.identifier.urihttps://hdl.handle.net/1805/47038
dc.language.isoen_US
dc.publisherElsevier
dc.relation.isversionof10.1016/j.celrep.2014.01.045
dc.relation.journalCell Reports
dc.rightsPublisher Policy
dc.sourcePMC
dc.subjectSquamous cell carcinoma
dc.subjectNeoplastic cell transformation
dc.subjectFibroblast growth factor 10
dc.subjectPTEN phosphohydrolase
dc.subjectSkin neoplasms
dc.titlePten loss induces autocrine FGF signaling to promote skin tumorigenesis
dc.typeArticle
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