Spirometry Versus Forced Oscillation to Assess Lung Function Outcome at 5 Years of Age

dc.contributor.authorTepper, Robert S.
dc.contributor.authorMilner, Kristin
dc.contributor.authorHarris, Julia
dc.contributor.authorLee, Brianna
dc.contributor.authorCunningham, Michelle
dc.contributor.authorTiller, Christina
dc.contributor.authorShorey‐Kendrick, Lyndsey E.
dc.contributor.authorSchilling, Diane
dc.contributor.authorBrownsberger, Julie
dc.contributor.authorMacDonald, Kelvin
dc.contributor.authorVu, Annette
dc.contributor.authorPark, Byung S.
dc.contributor.authorSpindel, Eliot R.
dc.contributor.authorMorris, Cynthia D.
dc.contributor.authorMcEvoy, Cindy T.
dc.contributor.departmentPediatrics, School of Medicine
dc.date.accessioned2025-02-20T12:18:56Z
dc.date.available2025-02-20T12:18:56Z
dc.date.issued2025
dc.description.abstractBackground: Spirometry is the gold standard for assessing airway function for clinical studies; however, obtaining high-quality data in young children remains challenging. Since the forced oscillation technique (FOT) requires less subject cooperations, there has been increasing interest in FOT, particularly in young children. We evaluated whether spirometry and FOT in young children provides comparable ability to detect a treatment effect. Methods: We recently reported in a randomized controlled trial that vitamin C compared to placebo treatment of mothers who smoked during pregnancy (MSDP) results in the offspring having significantly higher forced expiratory flows (FEFs) at 5-years of age, as well as significantly less wheeze at 4-6 years of age. In these same offspring, we also measured respiratory impedance using FOT at 8-Hz impedance at 3, 4, and 5 years of age. Results: Although spirometry demonstrated significantly increased FEFs in vitamin C compared to placebo-treatment group at 5 years of age (p < 0.001), we were not able to detect a similar treatment effect using FOT impedance. Conclusions: It may be challenging to obtain technically successful spirometry in preschool children; however, FEFs may provide a better outcome than single-frequency FOT impedance to assess improvements in airway function in these young subjects.
dc.eprint.versionFinal published version
dc.identifier.citationTepper RS, Milner K, Harris J, et al. Spirometry Versus Forced Oscillation to Assess Lung Function Outcome at 5 Years of Age. Pediatr Pulmonol. 2025;60(1):e27415. doi:10.1002/ppul.27415
dc.identifier.urihttps://hdl.handle.net/1805/45877
dc.language.isoen_US
dc.publisherWiley
dc.relation.isversionof10.1002/ppul.27415
dc.relation.journalPediatric Pulmonology
dc.rightsAttribution-NonCommercial 4.0 Internationalen
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0
dc.sourcePMC
dc.subjectAscorbic acid
dc.subjectElectric impedance
dc.subjectLung
dc.subjectOscillometry
dc.subjectPrenatal exposure delayed effects
dc.subjectSpirometry
dc.titleSpirometry Versus Forced Oscillation to Assess Lung Function Outcome at 5 Years of Age
dc.typeArticle
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