Brain-wide genome-wide colocalization study for integrating genetics, transcriptomics and brain morphometry in Alzheimer’s disease

dc.contributor.authorBao, Jingxuan
dc.contributor.authorWen, Junhao
dc.contributor.authorWen, Zixuan
dc.contributor.authorYang, Shu
dc.contributor.authorCui, Yuhan
dc.contributor.authorYang, Zhijian
dc.contributor.authorErus, Guray
dc.contributor.authorSaykin, Andrew J.
dc.contributor.authorLong, Qi
dc.contributor.authorDavatzikos, Christos
dc.contributor.authorShen, Li
dc.contributor.departmentRadiology and Imaging Sciences, School of Medicine
dc.date.accessioned2024-03-22T13:41:13Z
dc.date.available2024-03-22T13:41:13Z
dc.date.issued2023
dc.description.abstractAlzheimer’s disease (AD) is one of the most common neurodegenerative diseases. However, the AD mechanism has not yet been fully elucidated to date, hindering the development of effective therapies. In our work, we perform a brain imaging genomics study to link genetics, single-cell gene expression data, tissue-specific gene expression data, brain imaging-derived volumetric endophenotypes, and disease diagnosis to discover potential underlying neurobiological pathways for AD. To do so, we perform brain-wide genome-wide colocalization analyses to integrate multidimensional imaging genomic biobank data. Specifically, we use (1) the individual-level imputed genotyping data and magnetic resonance imaging (MRI) data from the UK Biobank, (2) the summary statistics of the genome-wide association study (GWAS) from multiple European ancestry cohorts, and (3) the tissue-specific cis-expression quantitative trait loci (cis-eQTL) summary statistics from the GTEx project. We apply a Bayes factor colocalization framework and mediation analysis to these multi-modal imaging genomic data. As a result, we derive the brain regional level GWAS summary statistics for 145 brain regions with 482,831 single nucleotide polymorphisms (SNPs) followed by posthoc functional annotations. Our analysis yields the discovery of a potential AD causal pathway from a systems biology perspective: the SNP chr10:124165615:G>A (rs6585827) mutation upregulates the expression of BTBD16 gene in oligodendrocytes, a specialized glial cells, in the brain cortex, leading to a reduced risk of volumetric loss in the entorhinal cortex, resulting in the protective effect on AD. We substantiate our findings with multiple evidence from existing imaging, genetic and genomic studies in AD literature. Our study connects genetics, molecular and cellular signatures, regional brain morphologic endophenotypes, and AD diagnosis, providing new insights into the mechanistic understanding of the disease. Our findings can provide valuable guidance for subsequent therapeutic target identification and drug discovery in AD.
dc.eprint.versionAuthor's manuscript
dc.identifier.citationBao J, Wen J, Wen Z, et al. Brain-wide genome-wide colocalization study for integrating genetics, transcriptomics and brain morphometry in Alzheimer's disease. Neuroimage. 2023;280:120346. doi:10.1016/j.neuroimage.2023.120346
dc.identifier.urihttps://hdl.handle.net/1805/39431
dc.language.isoen_US
dc.publisherElsevier
dc.relation.isversionof10.1016/j.neuroimage.2023.120346
dc.relation.journalNeuroImage
dc.rightsPublisher Policy
dc.sourcePMC
dc.subjectAlzheimer’s disease
dc.subjectImaging-genetics
dc.subjectMulti-modality
dc.subjectColocalization
dc.subjectMediation analysis
dc.titleBrain-wide genome-wide colocalization study for integrating genetics, transcriptomics and brain morphometry in Alzheimer’s disease
dc.typeArticle
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