PAK1 limits the expression of the pro-apoptotic protein Bad in pancreatic islet β-cells

Date
2012-09-08
Language
American English
Embargo Lift Date
Committee Members
Degree
Degree Year
Department
Grantor
Journal Title
Journal ISSN
Volume Title
Found At
Elsevier
Can't use the file because of accessibility barriers? Contact us with the title of the item, permanent link, and specifics of your accommodation need.
Abstract

Human type 2 diabetes is associated with β-cell apoptosis, and human islets from diabetic donors are ∼80% deficient in PAK1 protein. Toward addressing linkage of PAK1 to β-cell survival, PAK1-siRNA targeted MIN6 pancreatic β-cells were found to exhibit increased caspase-3 cleavage, cytosolic cytochrome-C and the pro-apoptotic protein Bad. PAK1(+/-) heterozygous mouse islets recapitulated the upregulation of Bad protein expression, as did hyperglycemic treatment of human or mouse islets; Bad levels were exacerbated most in PAK1(+/-) islets subjected to hyperglycemic stress. These data implicate PAK1 in β-cell survival via quenching of Bad protein expression, and suggest PAK1 as potential molecular target to preserve β-cell mass.

Description
item.page.description.tableofcontents
item.page.relation.haspart
Cite As
Wang Z, Thurmond DC. PAK1 limits the expression of the pro-apoptotic protein Bad in pancreatic islet β-cells. FEBS Open Bio. 2012;2:273-277. Published 2012 Sep 8. doi:10.1016/j.fob.2012.09.001
ISSN
Publisher
Series/Report
Sponsorship
Major
Extent
Identifier
Relation
Journal
FEBS Open Bio
Source
PMC
Alternative Title
Type
Article
Number
Volume
Conference Dates
Conference Host
Conference Location
Conference Name
Conference Panel
Conference Secretariat Location
Version
Final published version
Full Text Available at
This item is under embargo {{howLong}}