Enhancing predicted fluoride varnish efficacy and post-treatment compliance by means of calcium-containing gummy bears

dc.contributor.authorLippert, Frank
dc.contributor.authorAl Dehailan, Laila
dc.contributor.authorCastiblanco, Gina A.
dc.contributor.authorTagelsir, Azza
dc.contributor.authorBuckley, Christine
dc.contributor.authorEckert, George J.
dc.contributor.departmentCariology, Operative Dentistry and Dental Public Health, School of Dentistryen_US
dc.date.accessioned2018-04-20T18:24:32Z
dc.date.available2018-04-20T18:24:32Z
dc.date.issued2018
dc.description.abstractObjectives This study determined whether consumption of calcium-containing gummies prior to fluoride varnish application enhances plaque fluoride retention and compliance with post-varnish application instructions. Methods The present study followed a multi-center, parallel, randomized, and laboratory analyst-blind design. Following IRB approval, parent consent and child assent, 44 subjects (7–12 years), were randomized to either gummy or no-gummy study groups. A baseline plaque sample was obtained after a wash-out period. Fluoride varnish (5% NaF) was applied; subjects in the gummy group received two calcium-containing gummies prior to varnish application. Subjects were given two questionnaires to complete (subject and parent) to investigate adherence to post-treatment instructions. Three days later, a second plaque sample was obtained. Plaque was analyzed for plaque fluid and solid fluoride concentrations. Fluoride data were analyzed using Wilcoxon Rank Sum tests, questionnaire data using Pearson chi-square tests. Results Plaque fluid fluoride did not change pre- to post-treatment in the gummy group (mean ± sd: 8.8 ± 5.7 μmol/l vs. 10.0 ± 6.3 μmol/l; p = 0.265) or in the no-gummy group (8.1 ± 4.4 μmol/l vs. 16.1 ± 20.0 μmol/l; p = 0.058). Groups were not different for plaque fluid fluoride pre-treatment (p = 1.000), post-treatment (p = 0.904), or change (p = 0.904). Plaque solid fluoride did not change pre- to post-treatment in the gummy group (0.89 ± 1.10 μmol/g vs. 1.37 ± 1.77 μmol/g; p = 0.073) or in the no-gummy group (0.68 ± 0.77 μmol/g vs. 2.01 ± 5.00 μmol/g; p = 0.190). Groups were not different for plaque solid fluoride pre-treatment (p = 1.000), post-treatment (p = 0.466), or change (p = 0.874). No significant differences were found between groups for questionnaire responses. Conclusion This study failed to demonstrate an effect of calcium-containing gummies in enhancing plaque fluoride retention.en_US
dc.eprint.versionAuthor's manuscripten_US
dc.identifier.citationLippert, F., Al Dehailan, L., Castiblanco, G. A., Tagelsir, A. A., Buckley, C., & Eckert, G. J. (2018). Enhancing predicted fluoride varnish efficacy and post-treatment compliance by means of calcium-containing gummy bears. Journal of Dentistry. https://doi.org/10.1016/j.jdent.2018.03.015en_US
dc.identifier.urihttps://hdl.handle.net/1805/15890
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.jdent.2018.03.015en_US
dc.relation.journalJournal of Dentistryen_US
dc.rightsPublisher Policyen_US
dc.sourceAuthoren_US
dc.subjectfluoride varnishen_US
dc.subjectplaqueen_US
dc.subjectcariesen_US
dc.titleEnhancing predicted fluoride varnish efficacy and post-treatment compliance by means of calcium-containing gummy bearsen_US
dc.typeArticleen_US
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