Estrogen receptor involvement in the response of human keratinocytes to ultraviolet B irradiation
Date
2014
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American English
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M.S.
Degree Year
2014
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Department of Biochemistry & Molecular Biology
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Indiana University
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Abstract
The signaling mechanisms involved in UVB-induced skin cancer are complex and although the scope of this work is inherently limited in focus, the findings may provide insight into how estrogen receptor signaling impacts cell growth, senescence, and apoptosis to protect keratinocytes. Additional signaling due to E2-activation of the estrogen receptor may provide back-up or redundant pathways in response to UVB.
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