Progress in Modeling and Targeting Inner Ear Disorders with Pluripotent Stem Cells
dc.contributor.author | Tang, Pei-Ciao | |
dc.contributor.author | Hashino, Eri | |
dc.contributor.author | Nelson, Rick F. | |
dc.contributor.department | Otolaryngology -- Head and Neck Surgery, School of Medicine | en_US |
dc.date.accessioned | 2020-11-25T15:53:43Z | |
dc.date.available | 2020-11-25T15:53:43Z | |
dc.date.issued | 2020-06-09 | |
dc.description.abstract | Sensorineural hearing loss and vestibular dysfunction are caused by damage to neurons and mechanosensitive hair cells, which do not regenerate to any clinically relevant extent in humans. Several protocols have been devised to direct pluripotent stem cells (PSCs) into inner ear hair cells and neurons, which display many properties of their native counterparts. The efficiency, reproducibility, and scalability of these protocols are enhanced by incorporating knowledge of inner ear development. Modeling human diseases in vitro through genetic manipulation of PSCs is already feasible, thereby permitting the elucidation of mechanistic understandings of a wide array of disease etiologies. Early studies on transplantation of PSC-derived otic progenitors have been successful in certain animal models, yet restoration of function and long-term cell survival remain unrealized. Through further research, PSC-based approaches will continue to revolutionize our understanding of inner ear biology and contribute to the development of therapeutic treatments for inner ear disorders. | en_US |
dc.identifier.citation | Tang, P.-C., Hashino, E., & Nelson, R. F. (2020). Progress in Modeling and Targeting Inner Ear Disorders with Pluripotent Stem Cells. Stem Cell Reports, 14(6), 996–1008. https://doi.org/10.1016/j.stemcr.2020.04.008 | en_US |
dc.identifier.issn | 2213-6711 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/24470 | |
dc.language.iso | en_US | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.isversionof | 10.1016/j.stemcr.2020.04.008 | en_US |
dc.relation.journal | Stem Cell Reports | en_US |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.source | PMC | en_US |
dc.subject | disease modeling | en_US |
dc.subject | inner ear | en_US |
dc.subject | organoid | en_US |
dc.subject | stem cells | en_US |
dc.subject | therapy | en_US |
dc.title | Progress in Modeling and Targeting Inner Ear Disorders with Pluripotent Stem Cells | en_US |
dc.type | Article | en_US |
Files
Original bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- main (24).pdf
- Size:
- 3.35 MB
- Format:
- Adobe Portable Document Format
- Description:
- Main article
License bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- license.txt
- Size:
- 1.99 KB
- Format:
- Item-specific license agreed upon to submission
- Description: