Acute drug effects on habitual and non-habitual responding in crossed high alcohol preferring mice
dc.contributor.author | Houck, Christa A. | |
dc.contributor.author | Grahame, Nicholas J. | |
dc.contributor.department | Psychology, School of Science | en_US |
dc.date.accessioned | 2019-09-03T16:39:50Z | |
dc.date.available | 2019-09-03T16:39:50Z | |
dc.date.issued | 2018-07 | |
dc.description.abstract | RATIONALE: Drug reward plays a central role in acquiring drug-seeking behavior. However, subjects may continue using drugs despite negative consequences because self-administration becomes habitual, and divorced from outcome values. Although a history of drug and alcohol use expedite habit acquisition, and in spite of the fact that self-administration leads to intoxication, the acute effects of drugs on habitual responding are not well understood. OBJECTIVES: We sought to observe how acute ethanol and amphetamine affect the balance between habitual and goal-directed behavior, as measured by a fluid-reinforced operant conditioning task. METHODS: Selectively bred crossed high-alcohol-preferring (cHAP) mice were trained on an operant conditioning task reinforced on a variable interval schedule with 1% banana solution, which was subsequently devalued via LiCl pairing in half the animals. Ethanol (1.0 g/kg), amphetamine (2.0 mg/kg), or saline was administered prior to a post-devaluation test. RESULTS: Overall, mice showed habitual behavior, but when divided into high- or low-responding groups based on training response rates, saline-treated, low-responding animals devalued, while saline-treated high-responding animals did not. Furthermore, amphetamine elicited devaluation even in high-responding animals, while ethanol prevented devaluation even in low-responding animals. CONCLUSIONS: These data show that ethanol shifts animals toward behaving habitually. This may illuminate why alcohol-intoxicated individuals display impaired judgment about the relative merits of drinking, and potentially serve as a mechanism by which intoxicated subjects resume previously devalued behaviors, such as comorbid drug use. These findings also show that high variable interval response rates facilitate a shift from goal-directed to habitual behavior. | en_US |
dc.eprint.version | Author's manuscript | en_US |
dc.identifier.citation | Houck, C. A., & Grahame, N. J. (2018). Acute drug effects on habitual and non-habitual responding in crossed high alcohol preferring mice. Psychopharmacology, 235(7), 2167–2175. doi:10.1007/s00213-018-4914-8 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/20736 | |
dc.language.iso | en_US | en_US |
dc.publisher | Springer Nature | en_US |
dc.relation.isversionof | 10.1007/s00213-018-4914-8 | en_US |
dc.relation.journal | Psychopharmacology | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | PMC | en_US |
dc.subject | Alcohol | en_US |
dc.subject | Amphetamine | en_US |
dc.subject | Habit expression | en_US |
dc.subject | High alcohol preferring | en_US |
dc.subject | Operant | en_US |
dc.subject | Selectively bred | en_US |
dc.title | Acute drug effects on habitual and non-habitual responding in crossed high alcohol preferring mice | en_US |
dc.type | Article | en_US |