Adenylosuccinic Acid: An Orphan Drug with Untapped Potential

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dc.contributor.authorRybalka, Emma
dc.contributor.authorKourakis, Stephanie
dc.contributor.authorBonsett, Charles A.
dc.contributor.authorMoghadaszadeh, Behzad
dc.contributor.authorBeggs, Alan H.
dc.contributor.authorTimpani, Cara A.
dc.contributor.departmentNeurology, School of Medicine
dc.date.accessioned2024-01-18T15:40:31Z
dc.date.available2024-01-18T15:40:31Z
dc.date.issued2023-05-31
dc.description.abstractAdenylosuccinic acid (ASA) is an orphan drug that was once investigated for clinical application in Duchenne muscular dystrophy (DMD). Endogenous ASA participates in purine recycling and energy homeostasis but might also be crucial for averting inflammation and other forms of cellular stress during intense energy demand and maintaining tissue biomass and glucose disposal. This article documents the known biological functions of ASA and explores its potential application for the treatment of neuromuscular and other chronic diseases.
dc.eprint.versionFinal published version
dc.identifier.citationRybalka E, Kourakis S, Bonsett CA, Moghadaszadeh B, Beggs AH, Timpani CA. Adenylosuccinic Acid: An Orphan Drug with Untapped Potential. Pharmaceuticals (Basel). 2023;16(6):822. Published 2023 May 31. doi:10.3390/ph16060822
dc.identifier.urihttps://hdl.handle.net/1805/38086
dc.language.isoen_US
dc.publisherMDPI
dc.relation.isversionof10.3390/ph16060822
dc.relation.journalPharmaceuticals
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourcePMC
dc.subjectADSSL1 myopathy
dc.subjectDuchenne muscular dystrophy
dc.subjectNrf2 activation
dc.subjectAdenylosuccinate
dc.subjectAdenylosuccinic acid
dc.subjectImmunometabolism
dc.subjectMetabolic disease
dc.subjectPurine metabolism
dc.subjectSkeletal muscle; succinyl-AMP
dc.titleAdenylosuccinic Acid: An Orphan Drug with Untapped Potential
dc.typeArticle
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