Accuracy of self-reported history of autoimmune disease: A pilot study
dc.contributor.author | O'Rourke, Julia A. | |
dc.contributor.author | Ravichandran, Caitlin | |
dc.contributor.author | Howe, Yamini J. | |
dc.contributor.author | Mullett, Jennifer E. | |
dc.contributor.author | Keary, Christopher J. | |
dc.contributor.author | Golas, Sara B. | |
dc.contributor.author | Hureau, Amrita R. | |
dc.contributor.author | McCormick, Morgan | |
dc.contributor.author | Chung, Jeanhee | |
dc.contributor.author | Rose, Noel R. | |
dc.contributor.author | McDougle, Christopher J. | |
dc.contributor.department | Psychiatry, School of Medicine | en_US |
dc.date.accessioned | 2019-08-28T14:22:12Z | |
dc.date.available | 2019-08-28T14:22:12Z | |
dc.date.issued | 2019-05-29 | |
dc.description.abstract | Research associating the increased prevalence of familial autoimmunity with neuropsychiatric disorders is reliant upon the ascertainment of history of autoimmune diseases from relatives. To characterize the accuracy of self-report, we compared self-reported diagnoses of 18 autoimmune diseases using an online self-report questionnaire to the electronic medical record (EMR) diagnoses in 1,013 adult (age 18-70 years) patients of a primary care clinic. For the 11 diseases meeting our threshold observed prevalence, we estimated sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for self-reported diagnoses under the assumption that EMR-based diagnoses were accurate. Six diseases out of 11 had either sensitivity or PPV below 50%, with the lowest PPV for dermatological and endocrinological diseases. Common errors included incorrectly self-reporting type 2 diabetes mellitus (DM), when type 1 DM was indicated by the EMR, and reporting rheumatoid arthritis when osteoarthritis was indicated by the EMR. Results suggest that ascertainment of familial autoimmunity through self-report contributes to inconsistencies and inaccuracies in studies of autoimmune disease history and that future studies would benefit from incorporating EMR review and biological measures. | en_US |
dc.identifier.citation | O'Rourke, J. A., Ravichandran, C., Howe, Y. J., Mullett, J. E., Keary, C. J., Golas, S. B., … McDougle, C. J. (2019). Accuracy of self-reported history of autoimmune disease: A pilot study. PloS one, 14(5), e0216526. doi:10.1371/journal.pone.0216526 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/20646 | |
dc.language.iso | en_US | en_US |
dc.publisher | PLOS | en_US |
dc.relation.isversionof | 10.1371/journal.pone.0216526 | en_US |
dc.relation.journal | Plos One | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.source | PMC | en_US |
dc.subject | Familial autoimmunity | en_US |
dc.subject | Neuropsychiatric disorders | en_US |
dc.subject | Autoimmune diseases | en_US |
dc.subject | Positive predictive value (PPV) | en_US |
dc.subject | Negative predictive value (NPV) | en_US |
dc.title | Accuracy of self-reported history of autoimmune disease: A pilot study | en_US |
dc.type | Article | en_US |