Regulatory miRNAs and lncRNAs in Skin Cancer: A Narrative Review

dc.contributor.authorNatarelli, Nicole
dc.contributor.authorBoby, Aleena
dc.contributor.authorAflatooni, Shaliz
dc.contributor.authorTran, Jasmine Thuy
dc.contributor.authorDiaz, Michael Joseph
dc.contributor.authorTaneja, Kamil
dc.contributor.authorForouzandeh, Mahtab
dc.contributor.departmentMedicine, School of Medicine
dc.date.accessioned2024-02-21T18:46:15Z
dc.date.available2024-02-21T18:46:15Z
dc.date.issued2023-08-06
dc.description.abstractNon-coding RNAs (ncRNAs) have a significant regulatory role in the pathogenesis of skin cancer, despite the fact that protein-coding genes have generally been the focus of research efforts in the field. We comment on the actions of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) in the current review with an eye toward potential therapeutic treatments. LncRNAs are remarkably adaptable, acting as scaffolding, guides, or decoys to modify key signaling pathways (i.e., the Wnt/β-catenin pathway) and gene expression. As post-transcriptional gatekeepers, miRNAs control gene expression by attaching to messenger RNAs and causing their degradation or suppression during translation. Cell cycle regulation, cellular differentiation, and immunological responses are all affected by the dysregulation of miRNAs observed in skin cancer. NcRNAs also show promise as diagnostic biomarkers and prognostic indicators. Unraveling the complexity of the regulatory networks governed by ncRNAs in skin cancer offers unprecedented opportunities for groundbreaking targeted therapies, revolutionizing the landscape of dermatologic care.
dc.eprint.versionFinal published version
dc.identifier.citationNatarelli N, Boby A, Aflatooni S, et al. Regulatory miRNAs and lncRNAs in Skin Cancer: A Narrative Review. Life (Basel). 2023;13(8):1696. Published 2023 Aug 6. doi:10.3390/life13081696
dc.identifier.urihttps://hdl.handle.net/1805/38569
dc.language.isoen_US
dc.publisherMDPI
dc.relation.isversionof10.3390/life13081696
dc.relation.journalLife
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.sourcePMC
dc.subjectlncRNA
dc.subjectMelanoma
dc.subjectmiRNA
dc.subjectmicroRNA
dc.subjectNon-coding RNA
dc.subjectSkin cancer
dc.titleRegulatory miRNAs and lncRNAs in Skin Cancer: A Narrative Review
dc.typeArticle
Files
Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
life-13-01696.pdf
Size:
1.55 MB
Format:
Adobe Portable Document Format
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.99 KB
Format:
Item-specific license agreed upon to submission
Description: