Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning

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dc.contributor.authorLahti, Jari
dc.contributor.authorTuominen, Samuli
dc.contributor.authorYang, Qiong
dc.contributor.authorPergola, Giulio
dc.contributor.authorAhmad, Shahzad
dc.contributor.authorAmin, Najaf
dc.contributor.authorArmstrong, Nicola J.
dc.contributor.authorBeiser, Alexa
dc.contributor.authorBey, Katharina
dc.contributor.authorBis, Joshua C.
dc.contributor.authorBoerwinkle, Eric
dc.contributor.authorBressler, Jan
dc.contributor.authorCampbell, Archie
dc.contributor.authorCampbell, Harry
dc.contributor.authorChen, Qiang
dc.contributor.authorCorley, Janie
dc.contributor.authorCox, Simon R.
dc.contributor.authorDavies, Gail
dc.contributor.authorDe Jager, Philip L.
dc.contributor.authorDerks, Eske M.
dc.contributor.authorFaul, Jessica D.
dc.contributor.authorFitzpatrick, Annette L.
dc.contributor.authorFohner, Alison E.
dc.contributor.authorFord, Ian
dc.contributor.authorFornage, Myriam
dc.contributor.authorGerring, Zachary
dc.contributor.authorGrabe, Hans J.
dc.contributor.authorGrodstein, Francine
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorSimonsick, Eleanor
dc.contributor.authorHolliday, Elizabeth G.
dc.contributor.authorJoshi, Peter K.
dc.contributor.authorKajantie, Eero
dc.contributor.authorKaprio, Jaakko
dc.contributor.authorKarell, Pauliina
dc.contributor.authorKleineidam, Luca
dc.contributor.authorKnol, Maria J.
dc.contributor.authorKochan, Nicole A.
dc.contributor.authorKwok, John B.
dc.contributor.authorLeber, Markus
dc.contributor.authorLam, Max
dc.contributor.authorLee, Teresa
dc.contributor.authorLi, Shuo
dc.contributor.authorLoukola, Anu
dc.contributor.authorLuck, Tobias
dc.contributor.authorMarioni, Riccardo E.
dc.contributor.authorMather, Karen A.
dc.contributor.authorMedland, Sarah
dc.contributor.authorMirza, Saira S.
dc.contributor.authorNalls, Mike A.
dc.contributor.authorNho, Kwangsik
dc.contributor.authorO'Donnell, Adrienne
dc.contributor.authorOldmeadow, Christopher
dc.contributor.authorPainter, Jodie
dc.contributor.authorPattie, Alison
dc.contributor.authorReppermund, Simone
dc.contributor.authorRisacher, Shannon L.
dc.contributor.authorRose, Richard J.
dc.contributor.authorSadashivaiah, Vijay
dc.contributor.authorScholz, Markus
dc.contributor.authorSatizabal, Claudia L.
dc.contributor.authorSchofield, Peter W.
dc.contributor.authorSchraut, Katharina E.
dc.contributor.authorScott, Rodney J.
dc.contributor.authorSimino, Jeannette
dc.contributor.authorSmith, Albert V.
dc.contributor.authorSmith, Jennifer A.
dc.contributor.authorStott, David J.
dc.contributor.authorSurakka, Ida
dc.contributor.authorTeumer, Alexander
dc.contributor.authorThalamuthu, Anbupalam
dc.contributor.authorTrompet, Stella
dc.contributor.authorTurner, Stephen T.
dc.contributor.authorvan der Lee, Sven J.
dc.contributor.authorVillringer, Arno
dc.contributor.authorVölker, Uwe
dc.contributor.authorWilson, Robert S.
dc.contributor.authorWittfeld, Katharina
dc.contributor.authorVuoksimaa, Eero
dc.contributor.authorXia, Rui
dc.contributor.authorYaffe, Kristine
dc.contributor.authorYu, Lei
dc.contributor.authorZare, Habil
dc.contributor.authorZhao, Wei
dc.contributor.authorAmes, David
dc.contributor.authorAttia, John
dc.contributor.authorBennett, David A.
dc.contributor.authorBrodaty, Henry
dc.contributor.authorChasman, Daniel I.
dc.contributor.authorGoldman, Aaron L.
dc.contributor.authorHayward, Caroline
dc.contributor.authorIkram, M. Arfan
dc.contributor.authorJukema, J. Wouter
dc.contributor.authorKardia, Sharon L.R.
dc.contributor.authorLencz, Todd
dc.contributor.authorLoeffler, Markus
dc.contributor.authorMattay, Venkata S.
dc.contributor.authorPalotie, Aarno
dc.contributor.authorPsaty, Bruce M.
dc.contributor.authorRamirez, Alfredo
dc.contributor.authorRidker, Paul M.
dc.contributor.authorRiedel-Heller, Steffi G.
dc.contributor.authorSachdev, Perminder S.
dc.contributor.authorSaykin, Andrew J.
dc.contributor.authorScherer, Martin
dc.contributor.authorSchofield, Peter R.
dc.contributor.authorSidney, Stephen
dc.contributor.authorStarr, John M.
dc.contributor.authorTrollor, Julian
dc.contributor.authorUlrich, William
dc.contributor.authorWagner, Michael
dc.contributor.authorWeir, David R.
dc.contributor.authorWilson, James F.
dc.contributor.authorWright, Margaret J.
dc.contributor.authorWeinberger, Daniel R.
dc.contributor.authorDebette, Stephanie
dc.contributor.authorEriksson, Johan G.
dc.contributor.authorMosley, Thomas H., Jr.
dc.contributor.authorLauner, Lenore J.
dc.contributor.authorvan Duijn, Cornelia M.
dc.contributor.authorDeary, Ian J.
dc.contributor.authorSeshadri, Sudha
dc.contributor.authorRäikkönen, Katri
dc.contributor.departmentRadiology and Imaging Sciences, School of Medicine
dc.date.accessioned2023-10-09T11:21:35Z
dc.date.available2023-10-09T11:21:35Z
dc.date.issued2022
dc.description.abstractUnderstanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal learning in adults without dementia or stroke (N = 53,637). We identified novel loci in the intronic region of CDH18, and at 13q21 and 3p21.1, as well as an expected signal in the APOE/APOC1/TOMM40 region. These results replicated in an independent sample. Functional and bioinformatic analyses supported many of these loci and further implicated POC1. We showed that polygenic score for verbal learning associated with brain activation in right parieto-occipital region during working memory task. Finally, we showed genetic correlations of these memory traits with several neurocognitive and health outcomes. Our findings suggest a role of several genomic loci in verbal memory processes.
dc.eprint.versionFinal published version
dc.identifier.citationLahti J, Tuominen S, Yang Q, et al. Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning. Mol Psychiatry. 2022;27(11):4419-4431. doi:10.1038/s41380-022-01710-8
dc.identifier.urihttps://hdl.handle.net/1805/36209
dc.language.isoen_US
dc.publisherSpringer Nature
dc.relation.isversionof10.1038/s41380-022-01710-8
dc.relation.journalMolecular Psychiatry
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourcePMC
dc.subjectGenetics
dc.subjectNeuroscience
dc.subjectShort-term memory
dc.subjectBrain
dc.subjectLearning
dc.subjectMultifactorial inheritance
dc.subjectVerbal learning
dc.titleGenome-wide meta-analyses reveal novel loci for verbal short-term memory and learning
dc.typeArticle
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