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Item 5-Aza-2’-Deoxycytidine (5-aza-dC) Mediated Crosslinking Improves Specific Identification of DNA Methyltransferase 3a (DNMT3a) Catalytic Sites(2022-11) Holland, Benjamin; He, Ming; Utturkar, Sagar; Gowher, HumairaItem Unraveling the Enigma: Diagnostic Complexity in a Case of Idiopathic Membranoproliferative Glomerulonephritis(National Kidney Foundation, 2026) Holland, Benjamin; Holland, Mitchell; Sadolikar, Ashish; Yadlapalli, Srinath; Friedman, AllonItem Clinical Impact and Sustainability of a Neonatal Nephrology Consult Program(2024-07) Holland, Benjamin; Kotlik, Mayra; Lowe, Kathryn; Wallace, Samantha; Latimer, Anna; Slagle, Cara; Starr, MichelleItem Approach to Care of the Infant with Congenital Kidney Failure(2024-09) Muff-Leutt, M, Riddle, S, McKenna, K, Slagle, C; Holland, Benjamin; Kesier, Amaris; Short, Kara; Bendel-Stenzel, Ellen; Starr, Michelle; Menon, Shina; Muff-Leutt, Melissa; Riddle, Stefanie; McKenna, Kristin; Slagle, CaraItem Understanding Neonatal Hypertension Consult Patterns and Acute Kidney Injury(2025-09) Yadav, Manas; Holland, Benjamin; Starr, Michelle; Slagle, CaraItem Fundamentally Flawed: Fundoscopy & Misdiagnosis of Idiopathic Intracranial Hypertension(2026-03-27) Woods, Casey; Montelongo, Anna; Reese, Morgan; Kanetkar, Sylee; Watkins, JoannaItem “I had just lost my daughter, and she is recommending that I never get pregnant again”: A qualitative pilot study of unhoused women’s experiences with reproductive care(2025-04-19) Woods, Casey; Shanks, Anthony; Messmore, Niki; Longtin, KristaItem Eugenics in Your Backyard?: OB/GYN Experiences of Unhoused Women(2024-07-26) Woods, Casey; Messmore, NikiItem Diagnostic challenges in HPV-independent vulvar pathology: differentiated vulvar intraepithelial neoplasia (dVIN) in the setting of lichen sclerosus(2025-03-30) McQuillan, Josie; Woods, Casey; Lewis, Elaina; Skelly, Mary; Kowal, RachelBackground: Vulvar neoaplasia is classified by human papillomavirus infection status. Detecting precursor lesions (vulvar intraepithelial neoplasia - VIN) is key to preventing invasive carcinoma. High-risk HPV-associated VIN or high-grade squamous intraepithelial lesion (HSIL) typically affects younger patients and shows classic histology with p16 overexpression. In contrast, HPV-independent or differentiated VIN (dVIN) mainly affects older women, often with chronic inflammatory dermatoses like lichen sclerosus. dVIN shows p16 negativity and distinct p53 patterns, with variants like verruciform/acanthotic VIN (vaVIN) lacking p53 mutations, complicating detection. Notably, HPV-independent VIN has a worse prognosis than HSIL. Case Description: An 81-year-old woman presented with vulvar swelling, redness, and pain. Clinical exam revealed erythema from the vulva to the perineum and a 1 cm ulcerated right vulvar lesion. Biopsy showed dVIN with negative p16 and p53 overexpression, along with lichen sclerosus. Wide local excision showed a 1.2 cm well-differentiated, HPV-independent SCC with positive margins near the urethra. Postoperative PET/CT showed no metastasis. Due to positive margins and urethral proximity, chemoradiation was started but discontinued after 3 weeks due to unrelated ICU-level illness. Clinical Significance: This case shows the importance of early screening for HPV-independent VIN, especially in those with lichen sclerosus. Pathologists should be vigilant in detecting VIN to prevent progression to vulvar SCC. Clinicians should screen post-menopausal, non-sexually active women, who may not report symptoms or seek screening. Conclusions: The subtle histology and overlap with chronic inflammatory dermatoses make HPV-independent VIN difficult to detect clinically and histologically. Routine screening and a low threshold for biopsy, especially in those with lichen sclerosus, are vital for better outcomes. Given these diagnostic challenges, increased clinician and pathologist awareness is essential for preventing vulvar SCC.Item Formal Screening for Eating Disorders in Context of Stimulant Use Disorder in Pregnancy(2024-03-22) Nickerson, Margaret; Gasway, Elsie; Cory, Madeline; Woods, Casey; Arnaudo, Camila