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Item Lack of Cultural and Language Concordant Nutrition Education for Hispanic/Latinx Individuals with CKD: A Call to Action(Wolters Kluwer, 2022) Perez, Luis M.; Biruete, Annabel; Nutrition and Dietetics, School of Health and Human SciencesItem Feeling gutted in chronic kidney disease (CKD): Gastrointestinal disorders and therapies to improve gastrointestinal health in individuals CKD, including those undergoing dialysis(Wiley, 2021-10-27) Biruete, Annabel; Shin, Andrea; Kistler, Brandon M.; Moe, Sharon M.; Nutrition and Dietetics, School of Health and Human SciencesChronic kidney disease (CKD) affects 9.1% of the population worldwide. CKD may lead to structural and functional gastrointestinal alterations, including impairment in the intestinal barrier, digestion and absorption of nutrients, motility, and changes to the gut microbiome. These changes can lead to increased gastrointestinal symptoms in people with CKD, even in early grades of kidney dysfunction. Gastrointestinal symptoms have been associated with lower quality of life and reduced nutritional status. Therefore, there has been considerable interest in improving gastrointestinal health in this clinical population. Gastrointestinal health can be influenced by lifestyle and medications, particularly in advanced grades of kidney dysfunction. Therapies focused on gastrointestinal health have been studied, including the use of probiotics, prebiotics, and synbiotics, yielding limited and conflicting results. This review summarizes the alterations in the gastrointestinal tract structure and function and provides an overview of potential nutritional interventions that kidney disease professionals can provide to improve gastrointestinal health in individuals with CKD.Item Home-delivered meals as an adjuvant to improve volume overload and clinical outcomes in hemodialysis(Oxford University Press, 2022-04-19) Perez, Luis M.; Biruete, Annabel; Wilund, Kenneth R.; Nutrition and Dietetics, School of Health and Human SciencesPatients on chronic hemodialysis are counseled to reduce dietary sodium intake to limit their thirst and consequent interdialytic weight gain (IDWG), chronic volume overload and hypertension. Low-sodium dietary trials in hemodialysis are sparse and mostly indicate that dietary education and behavioral counseling are ineffective in reducing sodium intake and IDWG. Additional nutritional restrictions and numerous barriers further complicate dietary adherence. A low-sodium diet may also reduce tissue sodium, which is positively associated with hypertension and left ventricular hypertrophy. A potential alternative or complementary approach to dietary counseling is home delivery of low-sodium meals. Low-sodium meal delivery has demonstrated benefits in patients with hypertension and congestive heart failure but has not been explored or implemented in patients undergoing hemodialysis. The objective of this review is to summarize current strategies to improve volume overload and provide a rationale for low-sodium meal delivery as a novel method to reduce volume-dependent hypertension and tissue sodium accumulation while improving quality of life and other clinical outcomes in patients undergoing hemodialysis.Item Effects of Animal Source Food Supplementation on Neurocognitive Outcomes of HIV-Affected Kenyan School-Aged Children: A Randomized, Double-blind, Controlled Intervention Trial(2016-10-10) Neumann, Charlotte G.; Loo, Kek Khee; Weiss, Robert E.; Sugar, Catherine; Chen, Qiaolin; Rizzo, Shemra; Ettyang, Grace; Ernst, Judith A.Assess the effects of animal source food (ASF) versus soy versus wheat biscuit supplementation on the neurocognitive performance of HIV-affected, nutritionally at-risk school-aged children in rural Kenya.Item Estimates of body composition in drug naive asymptomatic HIV-infected rural Kenyan women(2010-07-19) Ernst, Judith A.; Ettyang, G; Katschke, A; Lewis, B; Neumann, CTo compare methods that estimate body composition in drug naive asymptomatic HIV-infected rural Kenyan women enrolled in a randomized nutrition intervention field study that will determine if meat added to the diet prevents the loss of lean body massItem Zinc protoporphyrin in HIV+ drug naïve rural Kenyan women(2010-10-06) Ernst, Judith A.; Ettyang, G; Katschke, A; Neumann, CTo determine if ZPP/H is a good indicator of iron depletion in drug naïve asymptomatic HIV-infected rural Kenyan women who are of reproductive age and enrolled in a randomized nutrition intervention field study that will determine the impact of added meat, soy or wheat protein on iron status.Item Hand Grip Strength and Body Composition in HIV-Infected Rural Kenyan Women(2012-04-23) Ernst, Judith A.; Ettyang, Grace; Johnson, Cynthia; Nyandiko, Winstone; Siika, Abraham; Neumann, CharlotteTo determine if meat in the diets of HIV infected rural Kenyan women prevents the loss of strength and body mass in those not yet ill enough to warrant antiretroviral drugs.Item The effects of increased energy and protein intakes and highly active antiretroviral therapy on growth and body composition of HIV+ Romanian children.(Monduzzi Editore, 2000) Ernst, Judith A.; Heiser, C; Fineberg, N; Cuff, P; Dinu, M; Chintea, O; Vasile, R; Mullinax, M; Matusa, RDiet quality, growth and body composition were assessed over one year in 15 HIV+, prepubescent Romanian children. Those with highly active antiretroviral therapy (+HAART; n=5) vs medication naïve (-HAART; n=10) at Time 0 revealed a greater energy (E) intake in +HAART (p=0.01); both groups exceeded FAO recommended intakes for E and protein (PRO). No difference in age-adjusted weight (WT), height (HT), body mass index (BMI), arm fat (MAFA) or arm muscle was evident at baseline. Changes in z-scores of anthropometrics from 0 to 6 months, were greater in +HAART for WT (p=0.02), HT(p= 0.03), BMI (p=0.06), and MAFA (p <0.001); changes were not different from 6 to 12 months. We conclude that intakes exceeding recommendations for E and PRO are adequate to maintain growth in HIV-infected Romanian children; and HAART is associated with a greater caloric intake although this difference is not maintained over time.Item The microenvironment reprograms circuits in tumor cells(Informa UK (Taylor & Francis), 2015-01) Cai, Qingchun; Xu, Yan; Department of Obstetrics & Gynecology, IU School of MedicineIn the course of multistep oncogenesis, initially normal cells acquire several new functions that render them malignant. We have recently demonstrated that the peritoneal microenvironment promotes resistance to anoikis in ovarian cancer cells by reprogramming SRC/AKT/ERK signaling and metabolism. These findings have prognostic and therapeutic implications.Item HIV Infection and Nutrition Status: The Importance of Food in Disease Management(Global Livestock CRSP, UC Davis, 2008-11) Ernst, Judith A.; Ettyang, Grace; Neumann, Charlotte; Nyandiko, Winstone; Siika, AbrahamPreliminary evidence suggests that improved nutrition early in human immunodeficiency virus (HIV) infection may delay progression to acquired immunodeficiency syndrome (AIDS) and delay the initiation or improve the effectiveness of antiretroviral drug therapy (ART). The scientific community has evolved in its appreciation of the value of food as an integral component of comprehensive care for individuals with HIV infection and AIDS. It is now well recognized that those who are food insecure and malnourished are more likely to fail drug treatment regimens. Body mass index (BMI) < 18 at the initiation of ART is strongly predictive of death. In addition, weight loss during the first four weeks of ART is also associated with death. A higher BMI is protective and is associated with better responses with ART. Patient response to nutrition intervention, however, may be confounded by the stage of HIV progression and other infections. That is, those who are in the earlier stages of the disease may respond better to aggressive nutrition intervention. The HIV Nutrition Project (HNP), "Increasing Animal Source Foods in Diets of HIV-infected Kenyan Women and Their Children," will evaluate the effect of protein quality and micronutrients found in meat on the health and nutritional well-being of women living with HIV in rural Kenya and the health and development of their children. By means of a randomized nutrition feeding intervention, researchers will study if the inclusion of meat added as an ingredient to a biscuit, when compared to soy or wheat, will best protect the immune system and prevent severe infection, prevent the loss of body mass and enhance the quality of life. These women are not yet receiving antiretroviral drugs and therefore not yet experiencing metabolic inefficiencies associated with AIDS.