Browsing by Subject "targeted protein detection"

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    Targeted Protein Detection using an All-In-One Mass Spectrometry Cartridge
    (ACS, 2017-07) Zhang, Chengsen; Glaros, Trevor; Manicke, Nicholas E.; Chemistry and Chemical Biology, School of Science
    We developed a simple 3D printed cartridge for mass spectrometry (MS) targeted detection of plasma proteins, including post-translational modifications (PTMs). The cartridge uses an integrated antibody enrichment column to preconcentrate the protein target as well as a novel built-in substrate to ionize the protein targets for MS detection. We show several examples of using this cartridge to perform rapid detection of clinically significant proteoforms from plasma samples.