Browsing by Subject "protein kinase C alpha"

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    Elevated protein kinase C alpha expression may be predictive of tamoxifen treatment failure
    (Cancer Research UK, 2003-04-29) Tonetti, D.A.; Morrow, M.; Kidwai, N.; Gupta, A.; Badve, Sunil; Pathology and Laboratory Medicine, School of Medicine
    We previously reported that stable transfection of protein kinase C alpha (PKCα) into T47D human breast cancer cells results in tamoxifen (TAM)-resistant tumour growth. Relevance of PKCα expression in clinical specimens was determined by comparing PKCα expression in tumours from patients exhibiting disease recurrence with patients remaining disease-free following TAM treatment. Our results suggest that PKCα expression may predict TAM treatment failure.