Browsing by Subject "muscle torque recovery"

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    Myogenic tissue nanotransfection improves muscle torque recovery following volumetric muscle loss
    (Nature, 2022) Clark, Andrew; Ghatak, Subhadip; Guda, Poornachander Reddy; El Masry, Mohamed S.; Xuan, Yi; Sato, Amy Y.; Bellido, Teresita; Sen, Chandan K.; Surgery, School of Medicine
    This work rests on our non-viral tissue nanotransfection (TNT) platform to deliver MyoD (TNT) to injured tissue in vivo. TNT was performed on skin and successfully induced expression of myogenic factors. TNT was then used as a therapy 7 days following volumetric muscle loss (VML) of rat tibialis anterior and rescued muscle function. TNT is promising as VML intervention.