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Item Anomaly Detection and Inter-Sensor Transfer Learning on Smart Manufacturing Datasets(MDPI, 2023-01-02) Abdallah, Mustafa; Joung, Byung-Gun; Lee, Wo Jae; Mousoulis, Charilaos; Raghunathan, Nithin; Shakouri, Ali; Sutherland, John W.; Bagchi, Saurabh; Computer and Information Science, School of ScienceSmart manufacturing systems are considered the next generation of manufacturing applications. One important goal of the smart manufacturing system is to rapidly detect and anticipate failures to reduce maintenance cost and minimize machine downtime. This often boils down to detecting anomalies within the sensor data acquired from the system which has different characteristics with respect to the operating point of the environment or machines, such as, the RPM of the motor. In this paper, we analyze four datasets from sensors deployed in manufacturing testbeds. We detect the level of defect for each sensor data leveraging deep learning techniques. We also evaluate the performance of several traditional and ML-based forecasting models for predicting the time series of sensor data. We show that careful selection of training data by aggregating multiple predictive RPM values is beneficial. Then, considering the sparse data from one kind of sensor, we perform transfer learning from a high data rate sensor to perform defect type classification. We release our manufacturing database corpus (4 datasets) and codes for anomaly detection and defect type classification for the community to build on it. Taken together, we show that predictive failure classification can be achieved, paving the way for predictive maintenance.Item Assessment of Deep Learning Methods for Differentiating Autoimmune Disorders in Ultrasound Images(Medical University Publishing House Craiova, 2021) Vasile, Corina Maria; Udriştoiu, Anca Loredana; Ghenea, Alice Elena; Padureanu, Vlad; Udriştoiu, Ştefan; Gruionu, Lucian Gheorghe; Gruionu, Gabriel; Iacob, Andreea Valentina; Popescu, Mihaela; Medicine, School of MedicineAt present, deep learning becomes an important tool in medical image analysis, with good performance in diagnosing, pattern detection, and segmentation. Ultrasound imaging offers an easy and rapid method to detect and diagnose thyroid disorders. With the help of a computer-aided diagnosis (CAD) system based on deep learning, we have the possibility of real-time and non-invasive diagnosing of thyroidal US images. This paper proposed a study based on deep learning with transfer learning for differentiating the thyroidal ultrasound images using image pixels and diagnosis labels as inputs. We trained, assessed, and compared two pre-trained models (VGG-19 and Inception v3) using a dataset of ultrasound images consisting of 2 types of thyroid ultrasound images: autoimmune and normal. The training dataset consisted of 615 thyroid ultrasound images, from which 415 images were diagnosed as autoimmune, and 200 images as normal. The models were assessed using a dataset of 120 images, from which 80 images were diagnosed as autoimmune, and 40 images diagnosed as normal. The two deep learning models obtained very good results, as follows: the pre-trained VGG-19 model obtained 98.60% for the overall test accuracy with an overall specificity of 98.94% and overall sensitivity of 97.97%, while the Inception v3 model obtained 96.4% for the overall test accuracy with an overall specificity of 95.58% and overall sensitivity of 95.58.Item BERMUDA: a novel deep transfer learning method for single-cell RNA sequencing batch correction reveals hidden high-resolution cellular subtypes(BioMed Central, 2019-08-12) Wang, Tongxin; Johnson, Travis S.; Shao, Wei; Lu, Zixiao; Helm, Bryan R.; Zhang, Jie; Huang, Kun; Medical and Molecular Genetics, School of MedicineTo fully utilize the power of single-cell RNA sequencing (scRNA-seq) technologies for identifying cell lineages and bona fide transcriptional signals, it is necessary to combine data from multiple experiments. We present BERMUDA (Batch Effect ReMoval Using Deep Autoencoders), a novel transfer-learning-based method for batch effect correction in scRNA-seq data. BERMUDA effectively combines different batches of scRNA-seq data with vastly different cell population compositions and amplifies biological signals by transferring information among batches. We demonstrate that BERMUDA outperforms existing methods for removing batch effects and distinguishing cell types in multiple simulated and real scRNA-seq datasets.Item Combining transfer learning with retinal lesion features for accurate detection of diabetic retinopathy(Frontiers Media, 2022-11-08) Hassan, Doaa; Gill, Hunter Mathias; Happe, Michael; Bhatwadekar, Ashay D.; Hajrasouliha, Amir R.; Janga, Sarath Chandra; BioHealth Informatics, School of Informatics and ComputingDiabetic retinopathy (DR) is a late microvascular complication of Diabetes Mellitus (DM) that could lead to permanent blindness in patients, without early detection. Although adequate management of DM via regular eye examination can preserve vision in in 98% of the DR cases, DR screening and diagnoses based on clinical lesion features devised by expert clinicians; are costly, time-consuming and not sufficiently accurate. This raises the requirements for Artificial Intelligent (AI) systems which can accurately detect DR automatically and thus preventing DR before affecting vision. Hence, such systems can help clinician experts in certain cases and aid ophthalmologists in rapid diagnoses. To address such requirements, several approaches have been proposed in the literature that use Machine Learning (ML) and Deep Learning (DL) techniques to develop such systems. However, these approaches ignore the highly valuable clinical lesion features that could contribute significantly to the accurate detection of DR. Therefore, in this study we introduce a framework called DR-detector that employs the Extreme Gradient Boosting (XGBoost) ML model trained via the combination of the features extracted by the pretrained convolutional neural networks commonly known as transfer learning (TL) models and the clinical retinal lesion features for accurate detection of DR. The retinal lesion features are extracted via image segmentation technique using the UNET DL model and captures exudates (EXs), microaneurysms (MAs), and hemorrhages (HEMs) that are relevant lesions for DR detection. The feature combination approach implemented in DR-detector has been applied to two common TL models in the literature namely VGG-16 and ResNet-50. We trained the DR-detector model using a training dataset comprising of 1,840 color fundus images collected from e-ophtha, retinal lesions and APTOS 2019 Kaggle datasets of which 920 images are healthy. To validate the DR-detector model, we test the model on external dataset that consists of 81 healthy images collected from High-Resolution Fundus (HRF) dataset and MESSIDOR-2 datasets and 81 images with DR signs collected from Indian Diabetic Retinopathy Image Dataset (IDRID) dataset annotated for DR by expert. The experimental results show that the DR-detector model achieves a testing accuracy of 100% in detecting DR after training it with the combination of ResNet-50 and lesion features and 99.38% accuracy after training it with the combination of VGG-16 and lesion features. More importantly, the results also show a higher contribution of specific lesion features toward the performance of the DR-detector model. For instance, using only the hemorrhages feature to train the model, our model achieves an accuracy of 99.38 in detecting DR, which is higher than the accuracy when training the model with the combination of all lesion features (89%) and equal to the accuracy when training the model with the combination of all lesions and VGG-16 features together. This highlights the possibility of using only the clinical features, such as lesions that are clinically interpretable, to build the next generation of robust artificial intelligence (AI) systems with great clinical interpretability for DR detection. The code of the DR-detector framework is available on GitHub at https://github.com/Janga-Lab/DR-detector and can be readily employed for detecting DR from retinal image datasets.Item Deep Transferable Intelligence for Wearable Big Data Pattern Detection(2021-08) Gangadharan, Kiirthanaa; Zhang, Qingxue; King, Brian S.; Chien, Yung-Ping S.Biomechanical Big Data is of great significance to precision health applications, among which we take special interest in Physical Activity Detection (PAD). In this study, we have performed extensive research on deep learning-based PAD from biomechanical big data, focusing on the challenges raised by the need for real-time edge inference. First, considering there are many places we can place the motion sensors, we have thoroughly compared and analyzed the location difference in terms of deep learning-based PAD performance. We have further compared the difference among six sensor channels (3-axis accelerometer and 3-axis gyroscope). Second, we have selected the optimal sensor and the optimal sensor channel, which can not only provide sensor usage suggestions but also enable ultra-lowpower application on the edge. Third, we have investigated innovative methods to minimize the training effort of the deep learning model, leveraging the transfer learning strategy. More specifically, we propose to pre-train a transferable deep learning model using the data from other subjects and then fine-tune the model using limited data from the target-user. In such a way, we have found that, for single-channel case, the transfer learning can effectively increase the deep model performance even when the fine-tuning effort is very small. This research, demonstrated by comprehensive experimental evaluation, has shown the potential of ultra-low-power PAD with minimized sensor stream, and minimized training effort.Item Diagnostic Evidence GAuge of Single cells (DEGAS): a flexible deep transfer learning framework for prioritizing cells in relation to disease(BMC, 2022-02-01) Johnson, Travis S.; Yu, Christina Y.; Huang, Zhi; Xu, Siwen; Wang, Tongxin; Dong, Chuanpeng; Shao, Wei; Zaid, Mohammad Abu; Huang, Xiaoqing; Wang, Yijie; Bartlett, Christopher; Zhang, Yan; Walker, Brian A.; Liu, Yunlong; Huang, Kun; Zhang, Jie; Medicine, School of MedicineWe propose DEGAS (Diagnostic Evidence GAuge of Single cells), a novel deep transfer learning framework, to transfer disease information from patients to cells. We call such transferrable information "impressions," which allow individual cells to be associated with disease attributes like diagnosis, prognosis, and response to therapy. Using simulated data and ten diverse single-cell and patient bulk tissue transcriptomic datasets from glioblastoma multiforme (GBM), Alzheimer's disease (AD), and multiple myeloma (MM), we demonstrate the feasibility, flexibility, and broad applications of the DEGAS framework. DEGAS analysis on myeloma single-cell transcriptomics identified PHF19high myeloma cells associated with progression.Item Multi-Source and Source-Private Cross-Domain Learning For Visual Recognition(2022-05) Peng, Qucheng; Li, Lingxi; Ding, Zhengming; Zhang, Qingxue; King, BrianDomain adaptation is one of the hottest directions in solving annotation insufficiency problem of deep learning. General domain adaptation is not consistent with the practical scenarios in the industry. In this thesis, we focus on two concerns as below. First is that labeled data are generally collected from multiple domains. In other words, multi-source adaptation is a more common situation. Simply extending these single-source approaches to the multi-source cases could cause sub-optimal inference, so specialized multi-source adaptation methods are essential. The main challenge in the multi-source scenario is a more complex divergence situation. Not only the divergence between target and each source plays a role, but the divergences among distinct sources matter as well. However, the significance of maintaining consistency among multiple sources didn't gain enough attention in previous work. In this thesis, we propose an Enhanced Consistency Multi-Source Adaptation (EC-MSA) framework to address it from three perspectives. First, we mitigate feature-level discrepancy by cross-domain conditional alignment, narrowing the divergence between each source and target domain class-wisely. Second, we enhance multi-source consistency via dual mix-up, diminishing the disagreements among different sources. Third, we deploy a target distilling mechanism to handle the uncertainty of target prediction, aiming to provide high-quality pseudo-labeled target samples to benefit the previous two aspects. Extensive experiments are conducted on several common benchmark datasets and demonstrate that our model outperforms the state-of-the-art methods. Second is that data privacy and security is necessary in practice. That is, we hope to keep the raw data stored locally while can still obtain a satisfied model. In such a case, the risk of data leakage greatly decreases. Therefore, it is natural for us to combine the federated learning paradigm with domain adaptation. Under the source-private setting, the main challenge for us is to expose information from the source domain to the target domain while make sure that the communication process is safe enough. In this thesis, we propose a method named Fourier Transform-Assisted Federated Domain Adaptation (FTA-FDA) to alleviate the difficulties in two ways. We apply Fast Fourier Transform to the raw data and transfer only the amplitude spectra during the communication. Then frequency space interpolations between these two domains are conducted, minimizing the discrepancies while ensuring the contact of them and keeping raw data safe. What's more, we make prototype alignments by using the model weights together with target features, trying to reduce the discrepancy in the class level. Experiments on Office-31 demonstrate the effectiveness and competitiveness of our approach, and further analyses prove that our algorithm can help protect privacy and security.Item Optimal transport- and kernel-based early detection of mild cognitive impairment patients based on magnetic resonance and positron emission tomography images(BMC, 2022) Liu, Ziyu; Johnson, Travis S.; Shao, Wei; Zhang, Min; Zhang, Jie; Huang, Kun; Biostatistics and Health Data Science, School of MedicineBackground: To help clinicians provide timely treatment and delay disease progression, it is crucial to identify dementia patients during the mild cognitive impairment (MCI) stage and stratify these MCI patients into early and late MCI stages before they progress to Alzheimer's disease (AD). In the process of diagnosing MCI and AD in living patients, brain scans are collected using neuroimaging technologies such as computed tomography (CT), magnetic resonance imaging (MRI), or positron emission tomography (PET). These brain scans measure the volume and molecular activity within the brain resulting in a very promising avenue to diagnose patients early in a minimally invasive manner. Methods: We have developed an optimal transport based transfer learning model to discriminate between early and late MCI. Combing this transfer learning model with bootstrap aggregation strategy, we overcome the overfitting problem and improve model stability and prediction accuracy. Results: With the transfer learning methods that we have developed, we outperform the current state of the art MCI stage classification frameworks and show that it is crucial to leverage Alzheimer's disease and normal control subjects to accurately predict early and late stage cognitive impairment. Conclusions: Our method is the current state of the art based on benchmark comparisons. This method is a necessary technological stepping stone to widespread clinical usage of MRI-based early detection of AD.Item Pruning Convolution Neural Network (SqueezeNet) for Efficient Hardware Deployment(2018-12) Gaikwad, Akash S.; El-Sharkawy, Mohamed; Rizkalla, Maher; King, BrianIn recent years, deep learning models have become popular in the real-time embedded application, but there are many complexities for hardware deployment because of limited resources such as memory, computational power, and energy. Recent research in the field of deep learning focuses on reducing the model size of the Convolution Neural Network (CNN) by various compression techniques like Architectural compression, Pruning, Quantization, and Encoding (e.g., Huffman encoding). Network pruning is one of the promising technique to solve these problems. This thesis proposes methods to prune the convolution neural network (SqueezeNet) without introducing network sparsity in the pruned model. This thesis proposes three methods to prune the CNN to decrease the model size of CNN without a significant drop in the accuracy of the model. 1: Pruning based on Taylor expansion of change in cost function Delta C. 2: Pruning based on L2 normalization of activation maps. 3: Pruning based on a combination of method 1 and method 2. The proposed methods use various ranking methods to rank the convolution kernels and prune the lower ranked filters afterwards SqueezeNet model is fine-tuned by backpropagation. Transfer learning technique is used to train the SqueezeNet on the CIFAR-10 dataset. Results show that the proposed approach reduces the SqueezeNet model by 72% without a significant drop in the accuracy of the model (optimal pruning efficiency result). Results also show that Pruning based on a combination of Taylor expansion of the cost function and L2 normalization of activation maps achieves better pruning efficiency compared to other individual pruning criteria and most of the pruned kernels are from mid and high-level layers. The Pruned model is deployed on BlueBox 2.0 using RTMaps software and model performance was evaluated.Item Transfer learning for medication adherence prediction from social forums self-reported data(2018-12) Haas, Kyle D.; Ben-Miled, Zina; King, Brian; El-Sharkawy, MohamedMedication non-adherence and non-compliance left unaddressed can compound into severe medical problems for patients. Identifying patients that are likely to become non-adherent can help reduce these problems. Despite these benefits, monitoring adherence at scale is cost-prohibitive. Social forums offer an easily accessible, affordable, and timely alternative to the traditional methods based on claims data. This study investigates the potential of medication adherence prediction based on social forum data for diabetes and fibromyalgia therapies by using transfer learning from the Medical Expenditure Panel Survey (MEPS). Predictive adherence models are developed by using both survey and social forums data and different random forest (RF) techniques. The first of these implementations uses binned inputs from k-means clustering. The second technique is based on ternary trees instead of the widely used binary decision trees. These techniques are able to handle missing data, a prevalent characteristic of social forums data. The results of this study show that transfer learning between survey models and social forum models is possible. Using MEPS survey data and the techniques listed above to derive RF models, less than 5% difference in accuracy was observed between the MEPS test dataset and the social forum test dataset. Along with these RF techniques, another RF implementation with imputed means for the missing values was developed and shown to predict adherence for social forum patients with an accuracy >70%. This thesis shows that a model trained with verified survey data can be used to complement traditional medical adherence models by predicting adherence from unverified, self-reported data in a dynamic and timely manner. Furthermore, this model provides a method for discovering objective insights from subjective social reports. Additional investigation is needed to improve the prediction accuracy of the proposed model and to assess biases that may be inherent to self-reported adherence measures in social health networks.