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Browsing by Subject "Novel therapeutic targets"
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Item Asparagine, a critical limiting metabolite during glutamine starvation(Taylor & Francis, 2018-04-11) Jiang, Jie; Pavlova, Natalya N.; Zhang, Ji; Pediatrics, School of MedicineA challenge of targeting glutamine metabolism in cancer is that tumor cells develop various strategies to adapt to glutamine limitation. We found that asparagine plays a critical role in supporting protein synthesis during glutamine starvation, highlighting a possible approach to optimize the therapeutic efficacy of targeting glutamine metabolism in cancer.