Browsing by Subject "Mini-puberty"

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    Hormonal suppression of mini-puberty in a neonate with mosaic 45X/46XY disorder of sexual development
    (Elsevier, 2020-05-03) Kaefer, Martin; Eugster, Erica; Medicine, School of Medicine
    Disorders of Sex Development (DSD) are some of the most controversial and challenging conditions that pediatric urologists treat. This may be especially true in mosaic 45X/46XY DSD, due to the inability to ascertain in the neonatal period which gender identity will best suit a given child with this condition. It has therefore been proposed to forgo any irreversible surgical interventions. In order to address the concern of early testosterone production in a nonsurgical manner we describe a case in which we treat a patient with a GnRH agonist to block the early physiologic rise in testosterone during the neonatal mini-puberty.