Browsing by Subject "Liver X receptors"

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    Less cholesterol means better tumor killing for cytotoxic T9 cells
    (Rockefeller University Press, 2018-06-04) Griesenauer, Brad; Paczesny, Sophie; Pediatrics, School of Medicine
    In this issue, Ma et al. (https://doi.org/10.1084/jem.20171576) show that removal of cholesterol from CD8 T cells during type 9 differentiation increases their IL-9 production, persistence in vivo, and cytolytic function against tumors by preventing SUMOylation of liver X receptors.