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Item Reliability and Validity of the OrthoMechanics Sequential Analyzer(Office of the Vice Chancellor for Research, 2014-04-11) Ghoneima, Ahmed A.; Talaat, S.; Kaboudan, A.; Kula, Katherine S.Purpose: The aim of this study was to evaluate the reliability and validity of newly developed software in the assessment of orthodontic tooth movement three dimensionally. Methods: The sample consisted of pre- and post- treatment computed tomography scans and plaster dental models of 20 orthodontic subjects treated with a hyrax expander as a part of their comprehensive orthodontic treatment. Dental arch measurements, including arch widths, tooth inclinations and angulations, were measured on the scans using InvivoDental 3D imaging software version 5.1. The plaster dental models were laser scanned, superimposed, and measurements were obtained digitally using the new software. Agreement between the digital models and the CT measurements was evaluated using intraclass correlation coefficients (ICCs), paired t-tests, and Bland-Altman plots. A p-value of ≤ 0.05 was considered statistically significant. Results: High agreement (ICC > 0.9), a non-significant paired t-test, and no indication of agreement discrepancies were observed for most of the measured parameters. Conclusions: The new software program offers a valid and reliable tool concerning dental arch measurements obtained from 3D laser scanned models. It could be considered a possible practical method that helps the orthodontist evaluate the treatment progress in a non-invasive manner and without unnecessary radiation exposure. Funding: Indiana University Purdue University - Office of the Vice Chancellor for Research & the Funding Opportunities for Research Commercialization and Economics Success (FORCES).Item A Three-Dimensional Analysis of Maxillary Sinus Congestion in Unilateral Cleft Lip and Palate(Office of the Vice Chancellor for Research, 2014-04-11) Hale, Lindsay; Starbuck, John M.; Ghoneima, Ahmed A.; Kula, Katherine S.Cleft lip and palate (CLP) perturbs osseous and soft-tissue development of the nasolabial regions, often resulting in chronic maxillary sinusitis and mucosal thickening (MT) of the maxillary sinus. This preliminary study quantifies maxillary sinus MT in children with surgically repaired unilateral CLP. We hypothesize that maxillary sinus MT is increased in children with CLP relative to controls. We define "MT" as the difference between the entire maxillary sinus volume and airspace volume. Cone beam computed tomography (CBCT) images of 8-14 yr. old age- and sex-matched unilateral CLP patients (n = 10) and controls (n = 10) were obtained (IRB approval # 1210009813). Both maxillary sinus and airspace surface areas (SAs) were measured on each individual CBCT slice in coronal view. SA measurements were summed and multiplied by voxel size (0.4mm) to obtain a volume. Paired t-tests determined whether maxillary sinus volume, air volume, MT (i.e. maxillary sinus volume – airspace volume), and percentage of MT (i.e. MT/maxillary size x 100) differed. A p-value of ≤ 0.05 was considered significant. Intra-class correlation assessed reliability and was high (0.99). Significant differences were found for several measurements: Maxillary airspace (non-cleft side vs. right side control p-value = 0.002; cleft-side vs. left side control p-value = 0.004), MT (cleft-side vs. left side p-value = 0.009), and percentage of MT (non-cleft side vs. right side control p-value = 0.002, cleft-side vs. left side control p-value = 0.002). Maxillary airspace was decreased by 30% (non-cleft side) and by 33% (cleft side). Percentage of average MT was 40% (non-cleft side) and 42% (cleft side) of CLP patients, but only 9% (left and right side) in controls. Surgically repaired CLP patients exhibit decreased maxillary airspace and increased MT relative to controls. CLP deformities are associated with MT. 3D imaging is useful for quantitatively evaluating MT of the maxillary sinus.