Open Access Coronavirus-Related Works

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This collection includes works by campus authors that address topics relevant to the COVID-19 pandemic. If you know of other works that should be included in this collection or, if you have questions regarding the inclusion criteria, please contact the University Library Center for Digital Scholarship: digschol@iupui.edu.

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Parental origin of chromosome 15 deletion in Prader-Willi syndrome
(Elsevier, 1983-06-04) Butler, Merlin G.; Palmer, Catherine G.; Medical and Molecular Genetics, School of Medicine
WKY Fatty Rat as a Model of Obesity and Non-insulin-dependent Diabetes Mellitus
(Oxford, 1990-07) Peterson, Richard G.; Little, Leah A.; Neel, Mary-Ann; Anatomy and Cell Biology, School of Medicine
The Regulation of Pulmonary Immunity
(Elsevier, 1995) Lipscomb, Mary F.; Bice, David E.; Lyons, C. Richard; Schuyler, Mark R.; Wilkes, David; Department of Internal Medicine, University of Indiana School of Medicine
No evidence has emerged which suggests that the principles of immunity derived from studies on cells from other body sites are contradicted in the lung and its associated lymphoid tissue. What is clear, however, is that the environment dictates the types of cells, their relationship to one another, and what perturbing events will set in motion either the development of an "active" immune response or tolerance. Investigating mechanisms for the development of lung immunity has increased our understanding of how human diseases develop and is continuing to suggest new ways to manipulate pulmonary immune responses. Demonstration that lung cells regulate both nonspecific inflammation and immunity through the expression of adhesion molecules and the secretion of cytokines offers hope for ways to design more effective vaccines, enhance microbial clearance in immunosuppressed hosts, and to suppress manifestations of immunologically mediated lung disease. Important lung diseases targeted for intensive research efforts in the immediate future are tuberculosis, asthma, and fibrotic lung disease. Perhaps even the common cold might be conquered. Considering the pace of current research on lung immunity, it may not be too ambitious to predict that these diseases may be conquered in the next decade.
8-aminoquinolines effective against Pneumocystis carinii in vitro and in vivo
(American Society for Microbiology, 1999-10) Queener, Sherry F.; Bartlett, Marilyn S.; Nasr, Mohamed; Smith, James W.; Pharmacology and Toxicology, School of Medicine
The activities of 25 8-aminoquinolines were compared in tests assessing the ability of the compounds to inhibit the growth of Pneumocystis carinii in culture. Six compounds were effective at or below 0.03 microM: CDRI 80/53, NSC19894, NSC305805, NSC305812, WR182234, and primaquine. Four others were effective at between 0.2 and 0.03 microM: NSC305835, WR225448, WR238605, and WR242511. Fourteen drugs were also tested in a standard model of P. carinii pneumonia in rats at daily doses of 2 mg/kg of body weight in drinking water. CDRI 80/53, NSC305805, NSC305835, and WR225448 were extremely effective in the animal model. The effectiveness of WR238605, WR242511, and primaquine in the rat model has been reported elsewhere (M. S. Bartlett, S. F. Queener, R. R. Tidwell, W. K. Milhouse, J. D. Berman, W. Y. Ellis, and J. W. Smith, Antimicrob. Agents Chemother. 35:277-282, 1991). The length of the alkyl chain separating the nitrogens in the substituent at position 8 of the quinoline ring was a strong determinant of anti-P. carinii activity.
Rapid changes in shape and number of MHC class II expressing cells in rat airways after Mycoplasma pulmonis infection
(Elsevier, 2002-12) Umemoto, Eric Y.; Brokaw, James J.; Dupuis, Marc; McDonald, Donald M.; Anatomy & Cell Biology, School of Medicine
Mycoplasma pulmonis infection in rodents causes a chronic inflammatory airway disease with a strong immunological component, leading to mucosal remodeling and angiogenesis. We sought to determine the effect of this infection on the shape and number of dendritic cells and other major histocompatibility complex (MHC) class II expressing cells in the airway mucosa of Wistar rats. Changes in the shape of subepithelial OX6 (anti-MHC class II)-immunoreactive cells were evident in the tracheal mucosa 2 days after intranasal inoculation with M. pulmonis. By 1 week, the shape of the cells had changed from stellate to rounded (mean shape index increased from 0.42 to 0.77). The number of OX6-positive cells was increased 6-fold at 1 week and 16-fold at 4 weeks. Coincident with these changes, many columnar epithelial cells developed OX6 immunoreactivity, which was still present at 4 weeks. We conclude that M. pulmonis infection creates a potent immunologic stimulus that augments and transforms the OX6-immunoreactive cell population in the airways by changing the functional state of airway dendritic cells, initiating an influx of MHC class II expressing cells, and activating expression of MHC class II molecules by airway epithelial cells.
SARS Another Emerging Disease
(MAG, 2003-07) Palenik, Charles John; Biomedical and Applied Sciences, School of Dentistry
Severe acute respiratory syndrome, SARS, is an illness that has been recently reported in Asia, North America, Europe and Africa. SARS appears to be a new disease. The first known case of atypical pneumonia occurred on 16 November 2002 in Foshan City, Guangdong Province, China. However, its significance was not known until later. The disease soon spread to the rest of the Guangdong Province and then further points in South East Asia. The World Health Organization (WHO) started to track the disease actively during mid-February 2003.
A Consensus Action Agenda for Achieving the National Health Information Infrastructure
(Oxford University Press, 2004) Yasnoff, William A.; Humphreys, Betsy L.; Overhage, J. Marc; Detmer, Don E.; Brennan, Patricia Flatley; Morris, Richard W.; Middleton, Blackford; Bates, David W.; Fanning, John P.; Medicine, School of Medicine
BACKGROUND: Improving the safety, quality, and efficiency of health care will require immediate and ubiquitous access to complete patient information and decision support provided through a National Health Information Infrastructure (NHII). METHODS: To help define the action steps needed to achieve an NHII, the U.S. Department of Health and Human Services sponsored a national consensus conference in July 2003. RESULTS: Attendees favored a public-private coordination group to guide NHII activities, provide education, share resources, and monitor relevant metrics to mark progress. They identified financial incentives, health information standards, and overcoming a few important legal obstacles as key NHII enablers. Community and regional implementation projects, including consumer access to a personal health record, were seen as necessary to demonstrate comprehensive functional systems that can serve as models for the entire nation. Finally, the participants identified the need for increased funding for research on the impact of health information technology on patient safety and quality of care. Individuals, organizations, and federal agencies are using these consensus recommendations to guide NHII efforts.
Endemic mycosis
(Springer Nature, 2005) Hage, Chadi A.; Knox, Kenneth S.; Sarosi, George A.; Department of Medicine, Indiana University School of Medicine
HHS pandemic influenza plan. [Table of Contents]
(2005-11) United States. Department of Health and Human Services.
The official government plan for dealing with an outbreak of pandemic influenza. Includes an annotated list of web sites in Part 1, Appendix J. The Table of Contents includes the Preface and the Executive Summary. Part 1 of the document is the "Strategic plan". Part 2 of the document is "Public health guidance for state and local partners". Part 2(a) contains the Introduction and Supplements 1-2. Part 2(b) contains Supplements 3-11.
Bioinformatics
(Springer Nature, 2006) Altman, Russ B.; Mooney, Sean D.; Department of Medicine, Indiana University School of Medicine
After reading this chapter, you should know the answers to these questions: Why is sequence, structure, and biological pathway information relevant to medicine? Where on the Internet should you look for a DNA sequence, a protein sequence, or a protein structure? What are two problems encountered in analyzing biological sequence, structure, and function? How has the age of genomics changed the landscape of bioinformatics? What two changes should we anticipate in the medical record as a result of these new information sources? What are two computational challenges in bioinformatics for the future?

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