Indiana Clinical and Translational Sciences Institute (CTSI)

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https://hdl.handle.net/1805/4056
Founded in 2008, the Indiana Clinical and Translational Sciences Institute (CTSI) is a statewide research partnership among Indiana University, Purdue University, the University of Notre Dame, and Regenstrief Institute, along with a number of life sciences organizations, governmental entities and community groups. The Indiana CTSI also engages with the public at every level of research—from basic science to patient care. It has been continuously funded by multimillion-dollar grants from the National Institutes of Health since the Indiana CTSI’s founding in 2008 and is housed at the Indiana University School of Medicine.

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    CTSA 2 Community: www.ctsa2community.org
    (2011-08-31) Ackermann, Ronald; Hardwick, Emily; Comer, Karen; Hudson, Brenda; Odell, Jere D.; Arenson, Andrew; Barnett, Bill; McGuire, Patrick; Derr, Michelle; Reid, Tisha; Vandergraff, Donna; Marrero, David G.
    This poster describes the development an accessible, user-driven, and sustainable web resource for community and academic experts working together to identify, adopt, and implement a wide array of community engaged research infrastructures for enhancing community engagement in all forms of clinical and translational research. CTSA2Community aims to be a storage place for valuable resources referring to the set-up and running of a community engagement program. Resources are provided by experts in the field of community engagement.
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    Developing Common Metrics for the Clinical and Translational Science Awards (CTSAs): Lessons Learned.
    (Wiley, 2015-10) Rubio, Doris M.; Blank, Arthur E.; Dozier, Ann; Hites, Lisle; Gilliam, Victoria A.; Hunt, Joe; Rainwater, Julie; Trochim, William M.; Indiana CTSI
    The National Institutes of Health (NIH) Roadmap for Medical Research initiative, funded by the NIH Common Fund and offered through the Clinical and Translational Science Award (CTSA) program, developed more than 60 unique models for achieving the NIH goal of accelerating discoveries toward better public health. The variety of these models enabled participating academic centers to experiment with different approaches to fit their research environment.A central challenge related to the diversity of approaches is the ability to determine the success and contribution of each model. This paper describes the effort by the Evaluation Key Function Committee to develop and test a methodology for identifying a set of common metrics to assess the efficiency of clinical research processes and for pilot testing these processes for collecting and analyzing metrics. The project involved more than one-fourth of all CTSAs and resulted in useful information regarding the challenges in developing common metrics, the complexity and costs of acquiring data for the metrics, and limitations on the utility of the metrics in assessing clinical research performance. The results of this process led to the identification of lessons learned and recommendations for development and use of common metrics to evaluate the CTSA effort.
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    2016 Advances in Renal Imaging Symposium
    (Indiana University School of Medicine/IUPUI, 2016-11-15) IUPUI Imaging Research Symposium
    The primary objective of the “Advances in Renal Imaging” symposium is to provide a forum for nephrology researchers and imaging scientists to come together and discuss needed kidney imaging biomarkers and explore the development of imaging technologies designed to address specific renal imaging needs. The Symposium includes three sessions of oral presentations with invited speakers addressing the following general themes: 1) Need for advances in renal imaging and the identification of potential imaging biomarker targets; 2) Advances in renal microscopy methods for basic science renal research; 3) Advances in molecular, perfusion, and structural renal imaging.
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    Librarians in Action: The COVID-19 Evidence Based Medicine Rapid Response Team
    (InULA Notes, 2020-05) Hinrichs, Rachel J.; Blevins, Amy E.
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    Providing Evidence about the Pandemic: Librarian Roles on a Rapid Response Team for COVID-19
    (2021-05-27) Craven, Hannah J.; Hinrichs, Rachel J.; Pike, Caitlin A.; Blevins, Amy E.
    BACKGROUND: SARS-CoV-2 has led to a deluge of information. Health leaders/personnel need curated and synthesized information to aid their decision making regarding diagnosis, treatment, mitigation, reopening plans, etc. A collaboration involving the state department of health has been developed to respond to those needs. Several programs were created simultaneously, two of which depend on active librarian involvement. One focuses on rapid expert responses to questions from state leadership supported by annotated bibliographies. The other is a daily digest of emerging literature including reviews on patient care, law and ethics, communication, forecasting and surveillance, schools, and mitigation. DESCRIPTION: Librarians from several libraries at a university are responding to the need for synthesized high-quality information related to the pandemic. These librarians have expertise in the areas of evidence-based medicine, data management, public health, and law. From the beginning, librarians have been heavily involved in creating workflows related to project and data management. Project management included having a standard process for tracking questions, delivering information, and team development. Librarians developed the team through onboarding, defining roles, scheduling, consistent communication, and shared document templates. Librarians created data management processes such as citation management, readme files, file management/naming conventions, data backup, etc. Librarians encouraged adoption of creative commons license notices on public-facing work to make the information more accessible. Project assessment was built into workflows and includes tracking: questions, turn around time, updates, and return on investment. CONCLUSION: Since the inception of this program, librarians have answered over 108 questions and provided 18 updates to annotated bibliographies. The average turnaround time for creating annotated bibliographies is 16 hours with a range of 2-48 hours. In addition, librarians have provided searches to support over 900 blog posts for WISE Indiana. While the pandemic has been stressful, this project provided us with an outlet to support our state. In addition, this project has led to: increased visibility for librarians, salary savings for the library, and recognition for our contributions that led to the receipt of an Award for Excellence in Public Health from Dr. Kristina Box​, the State Health Commissioner for Indiana.
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    Cross-institutional collaborations for health equity research at a CTSA
    (2022-04-20) Whipple, Elizabeth C.; Ramirez, Mirian; Dolan, Levi; Hunt, Joe D.
    Objective/Goals: We were interested in health equity research for each CTSA-affiliated institution, specifically focusing on cross department and cross-campus co-authorship. We conducted a bibliometric analysis of our CTSA-funded papers relating to diversity and inclusion to identify cross department and cross-campus collaborations. Methods/Study Population: We worked with our CTSA’s Racial Justice, Diversity, Equity and Inclusion Task Force to conduct an environmental scan of diversity and inclusion research across our CTSA partner institutions. Using the Scopus database, searches were constructed to identify and retrieve the variety of affiliations for each of the CTSA authors, a health equity/health disparities search hedge, and all of our CTSA grant numbers. We limited the dates from the beginning of our CTSA in 2008-November 2021. We used PubMed to retrieve all MeSH terms for the articles. We used Excel to analyze the data, Python and NCBI’s Entrez Programming Utilities to analyze MeSH terms, and VOSviewer to produce the visualizations. Results/Anticipated Results: The results of this search yielded 94 articles overall. We broke these up into subsets (not mutually exclusive) to represent five of the researcher groups across our CTSA. We analyzed the overall dataset for citation count, normalized citation count, CTSA average authors, gender trends, and co-term analysis. We also developed cross department co-authorship maps and cross-institutional/group co-authorship maps. Discussion/Significance of Impact: This poster will demonstrate both the current areas where cross-departmental and cross-institutional collaboration exists among our CTSA authors, as well as identify potential existing areas for collaboration to occur. These findings may determine areas our CTSA can support to improve institutional performance in addressing health equity.
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    Health Equity Starts with Us: Recommendations from the IN-CTSI Racial Justice and Health Equity Task Force
    (Association for Clinical and Translational Sciences, 2022-04-20) Sotto-Santiago, Sylk; Tucker Edmonds, Brownsyne; Wiehe, Sarah; Moe, Sharon
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    Indiana CTSI Preclinical Innovation Think Tank Program
    (Association for Clinical and Translational Sciences, 2022-04-21) Portonovo, Padma; Garcia, Kara; Moe, Sharon
    The skills and knowledge required for successful commercialization of new technologies (intellectual property protection, SBIR/STTR funding, and startup creation) are very different than those for traditional academic research (scientific publication and R01-style grant funding). The Indiana CTSI Think Tank Program is designed to provide early guidance to academic and clinical investigators interested in advancing their discoveries to the market. The program is open to investigators from Indiana University (IU), Purdue University, or the University of Notre Dame; and includes a pool of advisors across these universities and industry around the state to provide investigators with a wide range of expertise and perspectives.