Office of Educational Affairs, IU School of Medicine

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The Sin of Exclusion: Applicability of Trials Encouraging Omission of Radiation Therapy to Nonwhite Patients With Breast Cancer
(ASCO, 2018-11) McClelland, Shearwood, III; Xanthopoulos, Eric P.; Mitin, Timur; Graduate Medical Education, School of Medicine
Common Molecular Alterations in Canine Oligodendroglioma and Human Malignant Gliomas and Potential Novel Therapeutic Targets
(Frontiers, 2019-08-14) Mitchell, Dana; Chintala, Sreenivasulu; Fetcko, Kaleigh; Henriquez, Mario; Tewari, Brij N.; Ahmed, Atique; Bentley, R. Timothy; Dey, Mahua; Neurological Surgery, School of Medicine
Spontaneous canine (Canis lupus) oligodendroglioma (ODG) holds tremendous potential as an immunocompetent large animal model of human malignant gliomas (MG). However, the feasibility of utilizing this model in pre-clinical studies depends on a thorough understanding of the similarities and differences of the molecular pathways associated with gliomas between the two species. We have previously shown that canine ODG has an immune landscape and expression pattern of commonly described oncogenes similar to that of human MG. In the current study, we performed a comprehensive analysis of canine ODG RNAseq data from 4 dogs with ODG and 2 normal controls to identify highly dysregulated genes in canine tumors. We then evaluated the expression of these genes in human MG using Xena Browser, a publicly available database. STRING-database inquiry was used in order to determine the suggested protein associations of these differentially expressed genes as well as the dysregulated pathways commonly enriched by the protein products of these genes in both canine ODG and human MG. Our results revealed that 3,712 (23%) of the 15,895 differentially expressed genes demonstrated significant up- or downregulation (log2-fold change > 2.0). Of the 3,712 altered genes, ~50% were upregulated (n = 1858) and ~50% were downregulated (n = 1854). Most of these genes were also found to have altered expression in human MG. Protein association and pathway analysis revealed common pathways enriched by members of the up- and downregulated gene categories in both species. In summary, we demonstrate that a similar pattern of gene dysregulation characterizes both human MG and canine ODG and provide additional support for the use of the canine model in order to therapeutically target these common genes. The results of such therapeutic targeting in the canine model can serve to more accurately predict the efficacy of anti-glioma therapies in human patients.
Unique Molecular Features in High-Risk Histology Endometrial Cancers
(MDPI, 2019-10-27) Pandita, Pooja; Wang, Xiyin; Jones, Devin E.; Collins, Kaitlyn; Hawkins, Shannon M.; Obstetrics and Gynecology, School of Medicine
Endometrial cancer is the most common gynecologic malignancy in the United States and the sixth most common cancer in women worldwide. Fortunately, most women who develop endometrial cancer have low-grade early-stage endometrioid carcinomas, and simple hysterectomy is curative. Unfortunately, 15% of women with endometrial cancer will develop high-risk histologic tumors including uterine carcinosarcoma or high-grade endometrioid, clear cell, or serous carcinomas. These high-risk histologic tumors account for more than 50% of deaths from this disease. In this review, we will highlight the biologic differences between low- and high-risk carcinomas with a focus on the cell of origin, early precursor lesions including atrophic and proliferative endometrium, and the potential role of stem cells. We will discuss treatment, including standard of care therapy, hormonal therapy, and precision medicine-based or targeted molecular therapies. We will also discuss the impact and need for model systems. The molecular underpinnings behind this high death to incidence ratio are important to understand and improve outcomes.
Submitting to MedEdPORTAL: Do it right the first time
(2020-03-06) Craven, Hannah J.; Dilly, Christen K.; Hinrichs, Rachel J.
Medical educators at Indiana University School of Medicine (IUSM) are encouraged to publish in MedEdPORTAL: The Journal of Teaching and Learning Resources. Published by the Association of American Medical Colleges (AAMC), MedEdPORTAL is a peer-reviewed, open-access journal for medical education scholarship. These publications contain complete curricula, including objectives, instructor guides, slides, and assessments, ready to be implemented in the classroom. When faculty members apply for promotion, MedEdPORTAL can demonstrate the quality of their work through peer-review, citation counts, and other usage reports. Despite submitting high quality learning modules, medical educators receive rejections from the MedEdPORTAL 62% of time. Reasons for rejection include insufficient educational context and assessment, mismatch of educational objectives and instructional content, and failure to build on existing curricula. Of immediately rejected submissions, 90% also have copyright issues. MedEdPORTAL is a member of the Open Access Scholarly Publishers Association (OASPA) and therefore has strict requirements for copyright and licensing images in the education materials. These requirements are difficult to navigate. For faculty who are not familiar with copyright and licensing, these barriers can be frustrating enough to deter them from submitting curricula. This workshop introduced MedEdPORTAL, described the submission process, and shared our strategies for putting together a successful submission. By the end of the workshop, participants were able to: • Identify curricula they have developed that would fit with the goals of MedEdPORTAL’s publishers • Use template to complete the Educational Summary Report (ESR) • Classify content as that which requires copyright permission, is in the public domain, or has a Creative Commons license • Navigate the process of manuscript submission and revision
Claim your online scholarly presence: Google Scholar
(2020-03-06) Ramirez, Mirian; Craven, Hannah J.; Whipple, Elizabeth C.
Claiming, maintaining, and tracking research output is crucial to a researcher’s continued visibility and impact. This workshop will cover several (ORCiD ID, MyNCBI, Google Scholar, ResearcherID) of the commonly used scholarly profile tools. Tracking scholarly output and cultivating information about a researcher's work is made possible with online scholarly profile tools. Attendees participated in hands on activities to set up profiles, and discover more information about tracking their impact going forward, and utilize existing connections between different scholarly profile tools. Learning objectives: • List reasons why maintaining scholarly profiles is important to researchers • Describe the benefits of several scholarly profile tools • Set up and/or update your scholarly profile(s)
Claim your online scholarly presence: ORCiD
(2020-03-06) Craven, Hannah J.; Ramirez, Mirian; Whipple, Elizabeth C.
Claiming, maintaining, and tracking research output is crucial to a researcher’s continued visibility and impact. Tracking scholarly output and cultivating information about a researcher's work is made possible with online scholarly profile tools. As the most widely accepted unique identifier for authors, ORCiD IDs are increasingly required for: paper submissions to journals, grant submissions, and various NIH research training and career development awards. Attendees participated in hands on activities to set up profiles, and discover more information about tracking their impact going forward, and utilize existing connections between different scholarly profile tools. Learning objectives: • List reasons why maintaining scholarly profiles is important to researchers • Describe the benefits of several scholarly profile tools • Set up and/or update your scholarly profile(s)
One School: Using Teach-Throughs to Ensure Consistency
(2020-03-06) Blevins, Amy E.; Menard, Laura M.
Introducing First Year Medical Students to Personalized Medicine Concepts in a Small Group Activity
(2020-03-06) Harrington, Maureen A.; Blevins, Amy E.; Foster, Erin D.; Pratt, Vickie; Sharpe, Stephanie
An individuals’ genetic profile is becomingly an increasingly important parameter in healthcare decisions. This small group activity was developed to introduce first year medical students in the Molecules to Cells and Tissues course to the concept and significance of Pharmacogenomics and personalized medicine. Additionally, this activity provided students with an opportunity to work with a large dataset and use the information to impact clinical decision making. This activity has two cases, takes student groups approximately 2 hours to complete, and requires internet access. Case materials are available through the learning management system Canvas, and include open-ended questions to guide students through the cases. In these cases students explore the functional significance of different alleles of a panel of cytochrome P450 genes. The group activity has the students examine a large data set of cytochrome P450 genes and cognate alleles to determine their prevalence in the local population and calculate the individuals’ gene scores. The students are then asked to explain the impact of the genotype (or gene score) on the resulting patient phenotype (i.e. the functional significance of the genotype). The first case involves a breast cancer survivor support group in which patients taking Taxol discuss lack of adequate pain relief from opioids and the potential impact of concomitant use of natural compounds/supplements on drug metabolism. The second case involves a patient presenting with recurrent stroke-like symptoms despite being on the anticoagulant medication clopidogrel. The patient is initially suspected to be non-compliant, but is later determined to be a poor metabolizer of the anticoagulant clopidogrelto its active form thus decreasing its efficacy. The expertise of the IUSM Medical Genetics research faculty was leveraged to provide a large data set of cytochrome P450 genes and cognate alleles. The selection of cytochrome P450 was based upon delivering content focused on the biochemistry of the enzyme system and provided an opportunity to highlight the drug interaction database available through IUSM Clinical Pharmacology (The FlockhartTable™ ; https://drug-interactions.medicine.iu.edu/). The addition of natural compounds was to draw students’ attention to the Natural Medicines database, which is the recommended source for evidence-based data on complementary and alternative medicine. Natural Medicines is available through the Ruth Lilly Medical Library and can be searched by substance or condition. It provides both a summary of the literature available on substances as well as the level of evidence or quality of studies done on the substance.
Using VR to Enhance Anatomy Education for Medical Imaging Learners
(2020-03-06) Misquith, Chelsea; Patterson, Debra
The Ruth Lilly Medical Library’s Nexus Collaborative Learning Lab (Nexus) and the Medical Imaging Technology (MIT) Program at IUSM have partnered to create a series of Virtual Reality (VR) modules to enhance student comprehension and retention of anatomy for Cardiac Interventional (CI), Computed Tomography (CT), Vascular Interventional (VI), and Magnetic Resonance Imaging (MRI). This presentation will introduce you to VR and its applications in medical education, and describe the VR service available through the Nexus. Learn how a VR app for anatomy education, 3D Organon VR, was used to create greater student-content interactivity and to add flexibility to instruction.
Optimizing Performance: Mental Skills Training to Make Average Performance Excellent
(2020-03-06) Anton, Nicholas; Dimitrios, Stefanidis

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