IUPUI Research Day 2010

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Transportation Active Safety Institute
(Office of the Vice Chancellor for Research, 2010-04-09) Ainslie, Paul; Chen, Yaobin; Justiss, Michael; Koskie, Sarah; O’Connor, Sean
Since its founding in February 2006, the mission of the Transportation Active Safety Institute (TASI) has been to advance the use of active safety systems to reduce vehicle crashes and save lives. TASI was one of 10 centers awarded IUPUI Signature Center funding in January, 2008. With core faculty drawn from ten departments representing eight schools, the Transportation Active Safety Institute (TASI) is a university-wide interdisciplinary center for advanced automotive-safety research and development on the IUPUI campus. Partnership with industry, government, and non-profit agencies ensures that university research activities complement existing technologies and address existing and future needs. TASI aims to provide a neutral forum for pre-competitive discussion and development of standards and test methodologies for establishing objective benefits of active-safety systems. TASI has established a driving simulator laboratory for research into driver behavior and for testing active-safety system performance. The state-of-the-art DriveSafety DS-600c Driving Simulator is providing a flexible and realistic driving environment for industry, government, and internally sponsored research. This reconfigurable platform allows TASI to test various sensors and driver interfaces, in order to determine effective and convenient solutions to challenges in enhancing safety. TASI held its third workshop, the International Workshop on Research in Active Safety Technology, August 10-11, 2009, in Indianapolis and is currently planning an international workshop on human factors for August 2010. TASI has established an active dialog with other vehicle safety centers around the world through our Global Academic Network for Active Safety.
Providing Jobs, Skills and Hope: A Communication Plan for Handi-Capable Hands
(Office of the Vice Chancellor for Research, 2010-04-09) Anderson, Lindsey; Henke, Ashley
This communication plan seeks to support a resource development campaign that is to be implemented by Handi-Capable Hands (HCH). With the overarching business development and associate recruitment goals in mind, a series of communication theory based recommendations were developed for HCH.
Analytical Redundancy Based Predictive Fault Tolerant Control of a Steer-By-Wire System Using Nonlinear Observer
(Office of the Vice Chancellor for Research, 2010-04-09) Anwar, Sohel; Niu, Wei
A nonlinear observer based analytical redundancy methodology is presented for fault tolerant control of a steer by wire (SBW) system. A long-range predictor based on Diophantine identity has been utilized to improve the fault detection efficiency. The overall predictive fault tolerant control strategy was then implemented and validated on a steer by wire hardware in loop bench. The experimental results showed that the overall robustness of the SBW system was not sacrificed through the usage of analytical redundancy for sensors along with the designed fault detection algorithm. Moreover, the experimental results indicate that the faults could be detected faster using the developed analytical redundancy based algorithms for attenuating-type faults.
Keep Indianapolis Beautiful: The I-70 Corridor Public Art Project; and The Community Hospital North Project
(Office of the Vice Chancellor for Research, 2010-04-09) Armstrong, Kathryn; Hardy, Jodie
In September 2008, Keep Indianapolis Beautiful contacted the Basile Center to explore the possibility of commissioning student artists for public sculpture projects along the I70 corridor from the Indianapolis International Airport to downtown Indianapolis. First year MFA Sculpture student Kathryn Armstrong received the first commission in March 2009. Kathryn worked throughout the summer months and into fall semester to fabricate her design, which consists of 34 pod-like forms of varying sizes and colors. Titled going home, the project was installed in January 2010 at the Holt Road interchange. In an effort to incorporate art into the healing process for their patients and families, Community Hospital North has created an ongoing rotating sculpture program with Herron and The Basile Center to add sculptures to three niches along the hospital's main entrance drive. Sculpture students experienced a site-visit to inspire them to create their concepts for a site-specific sculpture in which they must consider scale, interactivity, durability, and aesthetic appeal. The students presented their proposals to Community Hospital North, who in 2009 commissioned Jodie Hardy to create her piece Close-up to be added to their outdoor sculpture collection for three years. Through this partnership, a new sculpture will be added annually.
The Institute for Research on Social Issues
(Office of the Vice Chancellor for Research, 2010-04-09) Ford, David A.; Bell, David; Johnson, Daniel P.; Bao, Wan-Ning; Dickerson-Putman, Jeanette; Morrison, Wendy; Parrish-Sprowl, John; Wilson, Jeffrey S.; Wolf, James
The Institute for Research on Social Issues (IRSI) is a collection of collaborating centers and workgroups meant to foster funded research in support of faculty and students who can benefit from its research infrastructure. The poster highlights the activities of IRSI Centers and Workgroups. It features two major funded research projects. “Networks of Heterosexual Risk and HIV” examines the motivations for risk-reducing behaviors between HIV-positive individuals and their HIV-negative partners. Study findings will inform interventions for preventing HIV among partners at risk of infection. “Decision Support through Earth Science Research Results” seeks to augment the current Heat Watch/Warning System (HWWS) with NASA instruments and models used in conjunction with socioeconomic and heat-related mortality data. This activity will enable the production of a more spatially specific warning for areas of risk within the cities, a current limitation of the HWWS.
The Binational/Crosscultural Health Enhancement Center
(Office of the Vice Chancellor for Research, 2010-04-09) Bergman, Alicia April; Bigatti, Silvia M.; Clark Jr., Charles M.; Everetts, David R.; Kahn, Hilary E.; Lorant, Diane Estella; Maupome, Gerardo; Mays, Rose M.; Riner, Mary E.; Snodgrass, Michael David; Soto, Armando; Stelzner, Sarah M.; Whitehead, Dawn Michele; Wilson, Gregory A.; Yoder, Karen M.
The Binational/Cross-Cultural Health Enhancement Center (BiCCHEC) fosters multidisciplinary research collaborations that address the biological, cultural, historical, legal, behavioral and demographic issues that impact the health status of communities where Latinos are born and where they live in Indiana. Since its inception, BiCCHEC projects have been multidisciplinary, 80% of the projects involve two or more IUPUI schools. BiCCHEC projects are also collaborative, 70% of the projects have one or more community partners. BiCCHEC researchers have also established a strong commitment to teaching and service, actively involving students in research (25% of current projects are student led) and servicelearning activities, developing exchange programs through our partnerships and providing direct health services in community organized events. Signature center funds have been utilized to fund internal pilot projects. The current poster will highlight four of those projects that have received pilot funding from signature center funds and have resulted in external grant applications or have already received funding, or have resulted in peer reviewed-publications. These projects are considered representative of BiCCHEC’s activities, because of their collaborative, multidisciplinary and community-based nature and include: • Study on oral health disparities using community-based participatory research • Study on the attitudes regarding children with disabilities, beliefs regarding death, coping skills and supports used during bereavement in communities in Indiana and rural Mexico • Building of a bi-national research partnership for healthful eating and diabetes prevention among Mexican and Mexican-American children • Study on emigration and return migration in 20th Century Mexico: Across the border and back again • Study on the effects of migrants' acculturation on oral health and diet in Indianapolis and Tala, Jaliscco using social network theory
Hearing, Perception, and Language in Clinical and Typical Populations
(Office of the Vice Chancellor for Research, 2010-04-09) Miyamoto, Richard T.; Bergson, Tonya R.; Burns, Debra S.; Chin, Steven B.; Houston, Derek M.
The IUPUI Signature Center for Advanced Studies in Hearing, Perception, and Language is a multidisciplinary, multidepartmental, multischool center dedicated to the integration of knowledge and methodologies from different disciplines to study speech perception and production, music perception and production, language, and cognition in clinical populations across the lifespan. Examples of ongoing research include the assessment of adult cochlear implant users’ perception of pitch; pediatric cochlear implant users’ speech intelligibility, prosody, and vocal music production; infants’ perception of auditory labels for visual objects; and breast cancer survivors’ perception of musical patterns following chemotherapy. In one study, we documented differences in hearing and music cognition between breast cancer survivors who received adjuvant cancer treatment and healthy age- and educationmatched controls. Participants were 29 female breast cancer survivors and 29 healthy controls. All participants received an audiometric test to assess hearing and The Montreal Battery for Evaluation of Amusia, which assesses such perceptual areas as melodic organization, temporal organization, and melodic memory. Results showed a moderate negative correlation between hearing and melodic organization scores across all subjects. For music cognition variables, effect-size analyses of melodic organization tasks (contour, intervals, tonality) suggested that healthy controls scored better than breast cancer survivors, although not significantly. The Center for Advanced Studies in Hearing, Perception, and Language continues to apply both standard and innovative analysis methodology to address cognitive issues of relevance to both clinical and typical populations.
Pioglitazone, an Insulin Sensitizing Drug, Attenuates the Development of Kidney and Liver Disease in the PCK Rodent Model of Polycystic Kidney Disease
(Office of the Vice Chancellor for Research, 2010-04-09) Blazer-Yost, Bonnie L.; Haydon, Julie; Eggelston, Tracy; Chen, Jey-Hsin; Torres, Vicente E.; Gattone, Vincent
Polycystic kidney disease is a genetic disorder characterized by growth of fluid-filled cysts predominately in kidney and liver. The only treatment currently available is the removal/aspiration of the largest cysts or organ transplantation. Promising pharmaceutical agents in clinical trials interfere with the action of hormones that increase cAMP thereby inhibiting secretion of Cl-, and compensatory fluid flux, into the cysts. Other treatments proposed include chemotherapeutic and immunosuppressive drugs that interfere with cellular proliferation as well as with signaling pathways for Cl- secretion. Long-term use of these agents will have multiple side effects. Based on a recent observation that peroxisome proliferator activated receptor γ agonists such as Actos (pioglitazone) and Avandia (rosiglitazone) decrease mRNA levels of a Cl- transport protein and the Cl- secretory response to vasopressin stimulation in cultured renal cells, it is hypothesized that PPARγ agonists will inhibit cyst growth. The current studies show that a 7 or 14 week feeding regimen of 20 mg/Kg BW pioglitazone inhibits renal and hepatic bile duct cyst growth in a rodent model orthologous to human PKD. In addition, the degree of renal cortical fibrosis was diminished in the pioglitazone-treated animals after 14 weeks. These results suggest that PPARγ agonists may be effective in controlling both renal and hepatic cyst growth and renal fibrotic development in polycystic kidney disease.
IUPUI Center for Health Geographics
(Office of the Vice Chancellor for Research, 2010-04-09) Bodenhamer, David J.; Wilson, Jeffrey S.; Comer, Karen Frederickson
The IUPUI Center for Health Geographics develops and supports research innovation through integration of geographic information science, medical informatics, community informatics, and public health. Our areas of research emphasis include geospatial technologies and standards for health surveillance, spatial and temporal contexts of health behaviors and health outcomes, and space-time models for investigating disease and mortality trends. Our poster highlights our collaborations, which include interdisciplinary partnerships with investigators in the fields of geographic information science, social science, clinical epidemiology, medical informatics, and health services research.
IUPUI Center for Mathematical Biosciences
(Office of the Vice Chancellor for Research, 2010-04-09) Boukai, Benzion; Chin, Ray; Dziubek, Andrea; Fokin, Vladimir; Ghosh, Samiran; Kuznetsov, Alexey; Li, Fang; Li, Jiliang; Rader, Andrew; Rubchinsky, Leonid; Sarkar, Jyotirmoy; Guidoboni, Giovanna; Worth, Robert; Zhu, Luoding
At-Large Mission: “to serve as an umbrella center for spearheading research and programmatic activities in the general bio-mathematics area” • promote and facilitate faculty excellence in mathematical and Computational research in the biosciences; • provide a mechanism and an environment that fosters collaborative research activities across the mathematical sciences and the life and health sciences schools at IUPUI— specifically with the IUSOM; • provide foundations and resources for further strategic development in targeted areas of mathematical and computational biosciences research; and • create greater opportunities and increase competitiveness in seeking and procuring extramural funding.

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