Browsing by Author "Nelson, Jessica"

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    Aplidin (plitidepsin) is a novel anti-myeloma agent with potent anti-resorptive activity mediated by direct effects on osteoclasts
    (Impact Journals, 2019-04-12) Delgado-Calle, Jesus; Kurihara, Noriyoshi; Atkinson, Emily G.; Nelson, Jessica; Miyagawa, Kazuaki; Galmarini, Carlos Maria; Roodman, G. David; Bellido, Teresita; Medicine, School of Medicine
    Despite recent progress in its treatment, Multiple Myeloma (MM) remains incurable and its associated bone disease persists even after complete remission. Thus, identification of new therapeutic agents that simultaneously suppress MM growth and protect bone is an unmet need. Herein, we examined the effects of Aplidin, a novel anti-cancer marine-derived compound, on MM and bone cells. In vitro, Aplidin potently inhibited MM cell growth and induced apoptosis, effects that were enhanced by dexamethasone (Dex) and bortezomib (Btz). Aplidin modestly reduced osteocyte/osteoblast viability and decreased osteoblast mineralization, effects that were enhanced by Dex and partially prevented by Btz. Further, Aplidin markedly decreased osteoclast precursor numbers and differentiation, and reduced mature osteoclast number and resorption activity. Moreover, Aplidin reduced Dex-induced osteoclast differentiation and further decreased osteoclast number when combined with Btz. Lastly, Aplidin alone, or suboptimal doses of Aplidin combined with Dex or Btz, decreased tumor growth and bone resorption in ex vivo bone organ cultures that reproduce the 3D-organization and the cellular diversity of the MM/bone marrow niche. These results demonstrate that Aplidin has potent anti-myeloma and anti-resorptive properties, and enhances proteasome inhibitors blockade of MM growth and bone destruction.
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    The implications of desk arrangement on social interaction in a third grade classroom
    (Taylor & Francis, 2018) Wilburn, Victoria G.; Wasmuth, Sally; Fehr, Callie; Brokamp, Kristen; Shupe, Mallory; Hursey, Brianna; Ross, Katie; Nelson, Jessica; Occupational Therapy, School of Health and Human Sciences
    Numerous studies have illustrated that participation in occupations—defined as meaningful life activities—is essential to wellness (AOTA, 2014). Social interaction is an important area of occupational participation for children in their roles as students (AOTA, 2014). Classroom design can impact student social participation; however, there is a lack of current research focused on effects of classroom design on social interaction for all students. Rather, research has examined factors affecting social participation of certain subgroups of students in the classroom, such as those with chronic illness or deafness (Martinez, Carter & Legato, 2011; Martins & Gaudiot, 2012). While literature provides information about various subpopulations, in this paper we emphasize that social participation based on classroom design can facilitate or inhibit overall occupational participation for all children in the role of student.
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    When Faculty Downsizing and Student Success Collide
    (Wiley, 2018) Everly, Marcee; Berlin, Kathryn; Weber, Peggy; Peterson, Yasenka; Nelson, Jessica; Health Sciences, School of Health and Rehabilitation Sciences