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Browsing by Author "Lawrence, Brianna"
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Item Silver-Promoted Site-Selective Intramolecular Cyclization of 2-Methylthiobenzamide Through α-C(sp3)–H Functionalization(ACS, 2019-11) Yang, Ke; Niu, Ben; Ma, Zhiyan; Wang, Hui; Lawrence, Brianna; Ge, Haibo; Chemistry and Chemical Biology, School of ScienceSilver-mediated intramolecular α-C(sp3)–H bond functionalization of the methylthio group has been established in the presence of Selectfluor as an additive. This novel strategy provides efficient access to various diverse sulfur-based heterocycles with good yields and functional group compatibility. It is noteworthy that the completely novel benzooxathiin-4-imine skeletons were reported for the first time in this study.Item Transient ligand‐enabled transition metal‐catalysed C‐H functionalisation(Wiley, 2019) Niu, Ben; Yang, Ke; Lawrence, Brianna; Ge, Haibo; Chemistry and Chemical Biology, School of ScienceTransition metal‐catalysed C‐H bond functionalisation is one of the most efficient and powerful strategies in synthetic organic chemistry to derivatize otherwise inert sites of organic molecules for the construction of C‐C and C‐heteroatom bonds. However, additional steps are often required in order to install the directing groups to realize the positional functionalisation of the substrates. These tedious steps run counter to the step‐economical nature of the C‐H activation. In contrast, direct functionalisation of the substrate, utilizing the transient ligands, avoids the unnecessary steps for the prefunctionalisation of the substrates. In this mini review, we will provide a short journey for the major progress made in this field for the C‐H functionalisation on sp2 and sp3 carbon centres with different transient working modes, including the covalent, hydrogen, and ionic bonds.