Browsing by Author "Fried, Daniel"

Now showing 1 - 4 of 4
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    Cross-Polarization Optical Coherence Tomographic Assessment of In situ Simulated Erosive Tooth Wear
    (Wiley, 2021) Romero, Maria Jacinta Rosario H.; Bezerra, Savio J.C.; Fried, Daniel; Yang, Vincent; Lippert, Frank; Eckert, George J.; Zero, Domenick T.; Hara, Anderson Takeo; Cariology, Operative Dentistry and Dental Public Health, School of Dentistry
    This clinical study tested cross-polarization optical coherence tomography (CP-OCT) monitoring of erosive tooth wear (ETW). Twenty participants completed a 14-day/arm, 3-arm crossover study simulating different ETW severities. Participants received two enamel specimens (per arm) and were randomized to: severe (s-ETW, lemon juice/pH:2.5/4.25%wt/vol citric acid), moderate (m-ETW, grapefruit juice/pH:3.5/1.03%wt/vol citric acid), and non-ETW (water). Enamel thickness was measured with CP-OCT (day[D] 0, 7, 14) and micro-computed tomography (μ-CT; D14). Enamel surface loss was determined with CP-OCT and optical profilometry (OP; D7, D14). CP-OCT showed higher enamel surface loss for D14 than D7 for m-ETW (P = .009) and s-ETW (P = .040) and differentiated severity at D14 (s-ETW > non-ETW, P = .027). OP was able to differentiate surface loss between days (D7 < D14, P < .001) for m-ETW and s-ETW, and ETW severity effect after 7 and 14 days (non-ETW < m-ETW < s-ETW, P < .001). At D14, CP-OCT and μ-CT were positively correlated (r = .87, ICC = .62). CP-OCT showed potential as a tool for clinical ETW monitoring.
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    Exploratory Analysis of Objective Outcome Measures for the Clinical Assessment of Erosive Tooth Wear
    (MDPI, 2023-08-02) Romero, Maria Jacinta Rosario H.; Ungar, Peter S.; Fried, Daniel; Lippert, Frank; Zero, Domenick T.; Zunt, Susan; Eckert, George J.; Gutierrez Gossweiler, Ana; Elkington-Stauss, Dylan Jacob; Tamayo-Cabeza, Guillermo; Kelly, Adam B.; Bartels, Troy; Kita, Camille; Wewers, Elizabeth; Hara, Anderson T.; Cariology, Operative Dentistry and Dental Public Health, School of Dentistry
    This study proposed using enamel surface texture and thickness for the objective detection and monitoring of erosive tooth wear (ETW), comparing them to the standard subjective Basic Erosive Wear Evaluation (BEWE). Thirty-two subjects (n = 597 teeth) were enrolled in this longitudinal observational clinical study. Enamel thickness (by cross-polarization optical coherence tomography, CP-OCT) and 3D dental microwear parameters, i.e., area-scale fractal complexity (Asfc), anisotropy (Str), and roughness (Sa) (by white-light scanning confocal profilometry), were obtained from buccal surfaces. Buccal, occlusal, and lingual surfaces were scored for BEWE and the maximum score per tooth (BEWEMax) was determined at baseline and 12 months (M12). Data outcome relationships were evaluated (alpha = 0.05). Enamel thickness decreased (p < 0.001), BEWE scores, Sa, and Str increased (p < 0.001), while Asfc did not change at M12. Baseline BEWEBuccal correlated strongly with BEWEMax (r = 0.86, p < 0.001) and moderately with BEWELingual (r = 0.42, p < 0.001), but not with enamel thickness (r = 0.03, p = 0.43). Change (Δ) in surface texture outcomes correlated poorly but significantly with ΔBEWEBuccal (r = −0.15–0.16, p < 0.001) and did not correlate with Δenamel thickness (r = 0.02–0.09, p > 0.06). Teeth with BEWE progression revealed a greater increase in ΔSa and ΔStr. These findings suggest that enamel surface roughness can potentially determine ETW severity, and CP-OCT may be relevant for clinically monitoring enamel thickness.
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    Longitudinal assessment of dental erosion-abrasion by cross-polarization optical coherence tomography in vitro
    (SciELO, 2023) Romero, Maria Jacinta Rosario; Bezerra, Sávio José Cardoso; Fried, Daniel; Lippert, Frank; Eckert, George Joseph; Hara, Anderson Takeo; Biomedical and Applied Sciences, School of Dentistry
    This study tested a novel in vitro dental erosion-abrasion model and the performance of cross-polarization optical coherence tomography (CP-OCT) in longitudinally monitoring the simulated lesions. Thirty human enamel specimens were prepared and randomized to receive three dental erosion-abrasion (EA) protocols: severe (s-EA, lemon juice/pH:2.5/4.25%w/v citric acid), moderate (m-EA, grapefruit juice/pH:3.5/1.03%w/v citric acid) and no-EA (water, control). EA challenge was performed by exposing the specimens to acidic solutions 4x/day and to brushing 2x/day with 1:3 fluoridated toothpaste slurry, for 14 days. Enamel thickness measurements were obtained using CP-OCT at baseline (D0), 7 (D7) and 14 days (D14) and micro-computed tomography (micro-CT) at D14. Enamel surface loss was measured with both CP-OCT and optical profilometry at D0, D7 and D14. Data was analyzed with repeated-measures ANOVA and Pearson's correlation (r) (α = 0.05). CP-OCT enamel thickness decreased over time in the s-EA group (D0 >D7 > D14, p < 0.001) and m-EA group (D0 > D14, p = 0.019) but did not change in the no-EA group (p = 0.30). Overall, CP-OCT and micro-CT results at D14 correlated moderately (r = 0.73). CP-OCT surface loss was highest for s-EA (p <0.001) but did not differ between moderate and no-EA (p = 0.25). Enamel surface loss with profilometry increased with severity (no-EA>m-EA>s-EA, p < 0.001). D14 surface loss was higher than D7 for both methods except for the no-EA group with profilometry. CP-OCT and profilometry had moderate overall correlation (r = 0.70). Our results revealed that the currently proposed in vitro dental erosion-abrasion model is valid and could simulate lesions of different severities over time. CP-OCT was a suitable method for monitoring the EA lesions.
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    Monitoring of Simulated Erosive Tooth Wear by Cross-Polarization Optical Coherence Tomography
    (2019-06) Alghilan, Maryam Abdulkareem; Hara, Anderson T.; Lippert, Frank; Platt, Jeffrey A.; González-Cabezas, Carlos; Fried, Daniel
    Erosive tooth wear (ETW) is an emerging dental condition manifested clinically as tooth surface loss, eventually impairing the teeth’s structural integrity, function, and esthetics. Both research and practice are in need of a quantitative, non-destructive method to monitor ETW. Cross-polarization optical coherence tomography (CP-OCT), an advanced imaging tool, shows great potential to fulfill this need, but its feasibility and shortcomings remain unclear. In this dissertation, I explored the capability of CP-OCT to monitor ETW in three in vitro studies, one per chapter. Chapter 2 investigated the effects of enamel surface roughness and dental erosion severity on CP-OCT dental surface loss measurements. Chapter 3 tested the effects of enamel surface roughness and dental erosion on CP-OCT enamel thickness measurements at different simulated wear levels. Chapter 4 explored the ability of CP-OCT to quantify the thickness of natural and wornout enamel surfaces and to estimate longitudinally the wear depths resulting from simulated wear. I concluded: (1) enamel surface roughness did not affect CP-OCT measurements of enamel surface loss, however, the estimated error limited the appropriate assessment of the initial stages of dental erosion surface loss using CP-OCT; (2) enamel surface roughness and dental erosion did not affect CP-OCT enamel thickness measurements, and the CP-OCT differentiated the simulated enamel wear levels; and (3) CP-OCT quantified thickness of natural enamel before, during, and after the tooth wear simulation and allowed wear depth estimation following the simulated wear.