Browsing by Author "Duncan, Natalie A."

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    A validated measure of adherence to antibiotic prophylaxis in children with sickle cell disease
    (Dove Medical Press, 2016) Duncan, Natalie A.; Kronenberger, William G.; Hampton, Kisha C.; Bloom, Ellen M.; Rampersad, Angeli G.; Roberson, Christopher P.; Shapiro, Amy D.; Department of Psychiatry, IU School of Medicine
    BACKGROUND: Antibiotic prophylaxis is a mainstay in sickle cell disease management. However, adherence is estimated at only 66%. This study aimed to develop and validate a Sickle Cell Antibiotic Adherence Level Evaluation (SCAALE) to promote systematic and detailed adherence evaluation. METHODS: A 28-item questionnaire was created, covering seven adherence areas. General Adherence Ratings from the parent and one health care provider and medication possession ratios were obtained as validation measures. RESULTS: Internal consistency was very good to excellent for the total SCAALE (α=0.89) and four of the seven subscales. Correlations between SCAALE scores and validation measures were strong for the total SCAALE and five of the seven subscales. CONCLUSION: The SCAALE provides a detailed, quantitative, multidimensional, and global measurement of adherence and can promote clinical care and research.