Browsing by Author "De Vincenzo, John"
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Item False-negative Histoplasma antigen in acute pulmonary histoplasmosis: the value of urinary concentration by ultrafiltration and heat denaturation of serum proteins in detection of Histoplasma antigen(Lippincott, Williams & Wilkins, 2009-05) Srinivasan, Ashok; Kleiman, Martin B.; Debelenko, Larisa; Stokes, Dennis C.; De Vincenzo, John; Wheat, Joseph L.; Pediatrics, School of MedicineWe report an infant with localized pulmonary histoplasmosis in whom Histoplasma antibody assays, quantitative Histoplasma urine and serum antigen concentrations, and histopathologic findings of a mediastinal mass were nondiagnostic. A provisional diagnosis of histoplasmosis was established by using laboratory methods that increase the sensitivity of the antigen assay using ultrafiltration of urine and ethylenediaminetetraacetic acid/heat denaturation of serum proteins.