Browsing by Author "Croucher, Peter J."

Now showing 1 - 1 of 1
  • Thumbnail Image
    Item
    PLK1 Inhibition Induces Synthetic Lethality in Fanconi Anemia Pathway-Deficient Acute Myeloid Leukemia
    (American Association for Cancer Research, 2025) Sheth, Aditya S.; Chan, Ka-Kui; Liu, Sheng; Wan, Jun; Angus, Steve P.; Rhodes, Steven D.; Mitchell, Dana K.; Davis, Christopher; Ridinger, Maya; Croucher, Peter J.; Zeidan, Amer M.; Wijeratne, Aruna; Qian, Shaomin; Tran, Ngoc Tung; Sierra Potchanant, Elizabeth A.; Pediatrics, School of Medicine
    This work demonstrates that FA pathway mutations, which are frequently observed in sporadic AML, induce hypersensitivity to PLK1 inhibition, providing rationale for a novel synthetic lethal therapeutic strategy for this patient population.