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Browsing by Author "Clifft, Monica"
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Item COMPARISON OF I-123 THYROID UPTAKE PHANTOM VALUES: GAMMA CAM-ERA VERSUS UPTAKE PROBE(Office of the Vice Chancellor for Research, 2012-04-13) Swann, Sarah; Clifft, MonicaThe purpose of this study was to investigate whether gamma cameras and uptake probes give comparable uptake results using 123I capsules. Methods: During a month-long period, five standard 123I thyroid dose cap-sules (156-163 μCi) were placed into a neck phantom, and positioned 10 centimeters away from the uptake probes and pinhole collimators attached to two gamma cameras. Each capsule was counted sixty seconds in three trials per capsule, along with a sixty second background count. The counts measured by both uptake probes and gamma cameras were compared. Re-sults: Comparison between the gamma camera uptake values and the probe system uptake values were done. The Argus gamma camera had higher counts than the Transcam 80% of the time. The probe systems had higher counts than the gamma cameras 100% of the time. Conclusion: Probe A and Probe B had significant higher counts than the Transcam and the Argus camera.Item A Comparison of the Sensitivity and Specificity of I-123 Whole body scan and Serum Thyroglobulin for Follow-up Thyroid Cancer Patients(Office of the Vice Chancellor for Research, 2016-04-08) Almomen, Fatimah F.; Nielsen, Cybil; Clifft, Monica; Thomas, PamalaAbstract Does the I-123 WBS have more sensitivity and specificity than Tg level test in follow-up for thyroid cancer? A comparison of the sensitivity & specificity between I-123 whole body scan (I-123 WBS) and serum thyroglobulin (Tg) for follow-up patients who were treated with I-131 for thyroid cancer was conducted. Methods & material: The design of this study is Null hypothesis: I-123 WBS has equal sensitivity or greater than Tg test when predicting recurrence of thyroid cancer. Alternate hypothesis: I-123 WBS has less sensitivity than Tg test. The population of this study is a convenience sample consisted of 28 patients who met the following criteria: 1) had follicular or papillary thyroid cancer or both, 2) between the period 2013 to 2015, and 3) had serum Tg results and had undergone I-123 WBS after one year of iodine therapy. Any detectable Tg value was considered positive. Tg and I-123 WBS results were compared with the final impression, which was the radiologist determination from the patient history and other tests (besides Tg and I-123 WBS), We compared Sensitivity and Specificity for both tests Results: Tg had a higher sensitivity than I-123 WBS. Tg has 75% sensitivity while I-123 WBS has 73.3 % sensitivity. I-123 WBS had a specificity of 100% and Tg had a specificity of 91.7%. Positive predictive Value (PPV) for Tg was 92.3%. and I-123 WBS was 100%. Negative Predictive Value (NPV) for Tg was 73.3% and I-123 WBS was 75%. Conclusions: I-123 WBS should not be replaced by Tg. I-123 WBS has higher specificity.