Browsing by Author "Angus, Steve P."

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    PLK1 Inhibition Induces Synthetic Lethality in Fanconi Anemia Pathway-Deficient Acute Myeloid Leukemia
    (American Association for Cancer Research, 2025) Sheth, Aditya S.; Chan, Ka-Kui; Liu, Sheng; Wan, Jun; Angus, Steve P.; Rhodes, Steven D.; Mitchell, Dana K.; Davis, Christopher; Ridinger, Maya; Croucher, Peter J.; Zeidan, Amer M.; Wijeratne, Aruna; Qian, Shaomin; Tran, Ngoc Tung; Sierra Potchanant, Elizabeth A.; Pediatrics, School of Medicine
    This work demonstrates that FA pathway mutations, which are frequently observed in sporadic AML, induce hypersensitivity to PLK1 inhibition, providing rationale for a novel synthetic lethal therapeutic strategy for this patient population.