Statistical analysis of clinical trial data using Monte Carlo methods
dc.contributor.advisor | Gao, Sujuan | |
dc.contributor.advisor | Yu, Menggang | |
dc.contributor.author | Han, Baoguang | |
dc.contributor.other | Yu, Zhangsheng | |
dc.contributor.other | Liu, Yunlong | |
dc.date.accessioned | 2014-07-11T19:48:49Z | |
dc.date.available | 2014-07-11T19:48:49Z | |
dc.date.issued | 2014-07-11 | |
dc.degree.discipline | Biostatistics | en |
dc.degree.grantor | Indiana University | en |
dc.degree.level | Ph.D. | |
dc.description | Indiana University-Purdue University Indianapolis (IUPUI) | en_US |
dc.description.abstract | In medical research, data analysis often requires complex statistical methods where no closed-form solutions are available. Under such circumstances, Monte Carlo (MC) methods have found many applications. In this dissertation, we proposed several novel statistical models where MC methods are utilized. For the first part, we focused on semicompeting risks data in which a non-terminal event was subject to dependent censoring by a terminal event. Based on an illness-death multistate survival model, we proposed flexible random effects models. Further, we extended our model to the setting of joint modeling where both semicompeting risks data and repeated marker data are simultaneously analyzed. Since the proposed methods involve high-dimensional integrations, Bayesian Monte Carlo Markov Chain (MCMC) methods were utilized for estimation. The use of Bayesian methods also facilitates the prediction of individual patient outcomes. The proposed methods were demonstrated in both simulation and case studies. For the second part, we focused on re-randomization test, which is a nonparametric method that makes inferences solely based on the randomization procedure used in clinical trials. With this type of inference, Monte Carlo method is often used for generating null distributions on the treatment difference. However, an issue was recently discovered when subjects in a clinical trial were randomized with unbalanced treatment allocation to two treatments according to the minimization algorithm, a randomization procedure frequently used in practice. The null distribution of the re-randomization test statistics was found not to be centered at zero, which comprised power of the test. In this dissertation, we investigated the property of the re-randomization test and proposed a weighted re-randomization method to overcome this issue. The proposed method was demonstrated through extensive simulation studies. | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/4650 | |
dc.identifier.uri | http://dx.doi.org/10.7912/C2/2777 | |
dc.language.iso | en_US | en_US |
dc.subject | joint modeling, semicompeting risks, Bayesian,Minimization, randomization test | en_US |
dc.subject.lcsh | Monte Carlo method -- Research -- Evaluation -- Methodology | en_US |
dc.subject.lcsh | Biometry -- Simulation methods -- Research -- Statistics | en_US |
dc.subject.lcsh | Statistical hypothesis testing -- Case studies | en_US |
dc.subject.lcsh | Numerical analysis -- Data processing | en_US |
dc.subject.lcsh | Outcome assessment (Medical care) -- Case studies | en_US |
dc.subject.lcsh | Random variables -- Research | en_US |
dc.subject.lcsh | Bayesian statistical decision theory | en_US |
dc.subject.lcsh | Survival analysis (Biometry) -- Mathematical models | en_US |
dc.subject.lcsh | Failure time data analysis -- Mathematics | en_US |
dc.subject.lcsh | Mortality -- Mathematical models | en_US |
dc.subject.lcsh | Competing risks -- Research -- Methodology | en_US |
dc.subject.lcsh | Clinical trials -- Statistical methods | en_US |
dc.subject.lcsh | Medical statistics | en_US |
dc.subject.lcsh | Health risk assessment -- Statistical methods | en_US |
dc.subject.lcsh | Biology -- Data processing | en_US |
dc.subject.lcsh | Probabilities -- Data processing | en_US |
dc.subject.lcsh | Artificial intelligence -- Medical applications | en_US |
dc.title | Statistical analysis of clinical trial data using Monte Carlo methods | en_US |
dc.type | Thesis | en_US |
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