Phellinus linteus suppresses growth, angiogenesis and invasive behaviour of breast cancer cells through the inhibition of AKT signalling

dc.contributor.authorSliva, D.
dc.contributor.authorJedinak, A.
dc.contributor.authorKawasaki, J.
dc.contributor.authorHarvey, K.
dc.contributor.authorSlivova, V.
dc.contributor.departmentMedicine, School of Medicineen_US
dc.date.accessioned2020-12-11T16:42:03Z
dc.date.available2020-12-11T16:42:03Z
dc.date.issued2008-03-25
dc.description.abstracthe antitumour activity of a medicinal mushroom Phellinus linteus (PL), through the stimulation of immune system or the induction of apoptosis, has been recently described. However, the molecular mechanisms responsible for the inhibition of invasive behaviour of cancer cells remain to be addressed. In the present study, we demonstrate that PL inhibits proliferation (anchorage-dependent growth) as well as colony formation (anchorage-independent growth) of highly invasive human breast cancer cells. The growth inhibition of MDA-MB-231 cells is mediated by the cell cycle arrest at S phase through the upregulation of p27Kip1 expression. Phellinus linteus also suppressed invasive behaviour of MDA-MB-231 cells by the inhibition of cell adhesion, cell migration and cell invasion through the suppression of secretion of urokinase-plasminogen activator from breast cancer cells. In addition, PL markedly inhibited the early event in angiogenesis, capillary morphogenesis of the human aortic endothelial cells, through the downregulation of secretion of vascular endothelial growth factor from MDA-MB-231 cells. These effects are mediated by the inhibition of serine-threonine kinase AKT signalling, because PL suppressed phosphorylation of AKT at Thr308 and Ser473 in breast cancer cells. Taken together, our study suggests potential therapeutic effect of PL against invasive breast cancer.en_US
dc.eprint.versionFinal published versionen_US
dc.identifier.citationSliva, D., Jedinak, A., Kawasaki, J. et al. Phellinus linteus suppresses growth, angiogenesis and invasive behaviour of breast cancer cells through the inhibition of AKT signalling. Br J Cancer 98, 1348–1356 (2008). https://doi.org/10.1038/sj.bjc.6604319en_US
dc.identifier.urihttps://hdl.handle.net/1805/24582
dc.language.isoen_USen_US
dc.publisherCancer Research UKen_US
dc.relation.isversionof10.1038/sj.bjc.6604319en_US
dc.relation.journalBritish Journal of Canceren_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0*
dc.sourcePublisheren_US
dc.subjectPhellinus linteusen_US
dc.subjectinvasivenessen_US
dc.subjectangiogenesisen_US
dc.subjectAKTen_US
dc.titlePhellinus linteus suppresses growth, angiogenesis and invasive behaviour of breast cancer cells through the inhibition of AKT signallingen_US
dc.typeArticleen_US
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