Regulating the adaptive immune response to respiratory virus infection

Simple item page
dc.contributor.authorBraciale, Thomas J.
dc.contributor.authorSun, Jie
dc.contributor.authorKim, Taeg S.
dc.contributor.departmentPediatrics, IU School of Medicineen_US
dc.date.accessioned2020-04-01T11:46:26Z
dc.date.available2020-04-01T11:46:26Z
dc.date.issued2012
dc.descriptionThis article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
dc.description.abstractRecent years have seen several advances in our understanding of immunity to virus infection of the lower respiratory tract, including to influenza virus infection. Here, we review the cellular targets of viruses and the features of the host immune response that are unique to the lungs. We describe the interplay between innate and adaptive immune cells in the induction, expression and control of antiviral immunity, and discuss the impact of the infected lung milieu on moulding the response of antiviral effector T cells. Recent findings on the mechanisms that underlie the increased frequency of severe pulmonary bacterial infections following respiratory virus infection are also discussed.en_US
dc.identifier.citationBraciale, T. J., Sun, J., & Kim, T. S. (2012). Regulating the adaptive immune response to respiratory virus infection. Nature reviews. Immunology, 12(4), 295–305. https://doi.org/10.1038/nri3166en_US
dc.identifier.urihttps://hdl.handle.net/1805/22448
dc.language.isoen_USen_US
dc.publisherSpringer Natureen_US
dc.relation.isversionof10.1038/nri3166en_US
dc.relation.journalImmunologyen_US
dc.rightsThis article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
dc.sourcePMCen_US
dc.subjectDendritic cellsen_US
dc.subjectInfectionen_US
dc.subjectT cellsen_US
dc.subjectInflammationen_US
dc.subjectAlveolar macrophagesen_US
dc.subjectRespiratory tract diseasesen_US
dc.titleRegulating the adaptive immune response to respiratory virus infectionen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
41577_2012_Article_BFnri3166.pdf
Size:
672.23 KB
Format:
Adobe Portable Document Format
Description:
PHE PDF
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.99 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Open Access Coronavirus-Related Works