Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for Codeine Therapy in the Context of Cytochrome P450 2D6 (CYP2D6) Genotype

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dc.contributor.authorCrews, K.R.
dc.contributor.authorGaedigk, A.
dc.contributor.authorDunnenberger, H.M.
dc.contributor.authorKlein, T.E.
dc.contributor.authorShen, D.D.
dc.contributor.authorCallaghan, J.T.
dc.contributor.authorKharasch, E.D.
dc.contributor.authorSkaar, Todd C.
dc.date.accessioned2022-10-11T21:59:51Z
dc.date.available2022-10-11T21:59:51Z
dc.date.issued2012-02
dc.description.abstractCodeine is bioactivated to morphine, a strong opioid agonist, by the hepatic cytochrome P450 2D6 (CYP2D6); hence, the efficacy and safety of codeine as an analgesic are governed by CYP2D6 polymorphisms. Codeine has little therapeutic effect in patients who are CYP2D6 poor metabolizers, whereas the risk of morphine toxicity is higher in ultrarapid metabolizers. The purpose of this guideline (periodically updated at http://www.pharmgkb.org) is to provide information relating to the interpretation of CYP2D6 genotype test results to guide the dosing of codeine.en_US
dc.identifier.citationCrews KR, Gaedigk A, Dunnenberger HM, et al. Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for codeine therapy in the context of cytochrome P450 2D6 (CYP2D6) genotype. Clin Pharmacol Ther. 2012;91(2):321-326. doi:10.1038/clpt.2011.287en_US
dc.identifier.urihttps://hdl.handle.net/1805/30327
dc.language.isoen_USen_US
dc.publisherWileyen_US
dc.relation.isversionof10.1038/clpt.2011.287en_US
dc.subjectOpioid analgesicsen_US
dc.subjectCodeineen_US
dc.subjectCytochrome P-450 CYP2D6en_US
dc.subjectPharmacogeneticsen_US
dc.titleClinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for Codeine Therapy in the Context of Cytochrome P450 2D6 (CYP2D6) Genotypeen_US
dc.typeArticleen_US
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