The First Synthesis of the Antiangiogenic Homoisoflavanone, Cremastranone
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Date
2014
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American English
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Royal Society of Chemistry
Abstract
An antiangiogenic homoisoflavanone, cremastranone, was synthesized for the first time. This scalable synthesis, which includes selective demethylation, could be used to develop lead molecules to treat angiogenesis-induced eye diseases. Synthetic cremastranone inhibited the proliferation, migration and tube formation ability of human retinal microvascular endothelial cells, important steps in pathological angiogenesis.
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Lee, B., Basavarajappa, H. D., Sulaiman, R. S., Fei, X., Seo, S. Y., & Corson, T. W. (2014). The first synthesis of the antiangiogenic homoisoflavanone, cremastranone. Organic & biomolecular chemistry, 12(39), 7673-7677.
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Organic & Biomolecular Chemistry
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